Ignite Creation Date:
2024-05-06 @ 8:48 AM
Last Modification Date:
2024-10-26 @ 12:05 PM
Study NCT ID:
NCT02820207
Status:
COMPLETED
Last Update Posted:
2021-02-01
First Post:
2016-06-20
Brief Title:
Identification of Carotid Plague Vulnerability by Contrast Enhanced Ultrasound Correlation With Plague Histopathology
Sponsor:
Beijing Tsinghua Chang Gung Hospital
Organization:
Beijing Tsinghua Chang Gung Hospital
Study Overview
Official Title:
Vascular Surgery Department of Beijing Tsinghua Chang Gung Hospital
Status:
COMPLETED
Status Verified Date:
2020-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
OBJECTIVEBACKGROUND Intraplaque neovascularization is one of the most important risk factors for unstable carotid plaque This study was designed to evaluate whether carotid intraplaque neovascularization IPN can be accurately assessed by contrast enhanced ultrasound CEUS
METHODS Preoperative CEUS analysis of 50 carotid artery stenosis patients would be compared to histopathology performed on their plaques excised by carotid endarterectomy CEA with CD34 and MMP9 staining
METHODS Preoperative CEUS analysis of 50 carotid artery stenosis patients would be compared to histopathology performed on their plaques excised by carotid endarterectomy CEA with CD34 and MMP9 staining
Detailed Description:
1 To enroll 50 cases of patients suffering from carotid artery stenosis continuously the investigators perform contrast enhanced ultrasound on patients for identifying the vulnerable plagues and taking high resolution MR inspection to analysis those plagues at the same time
2 All patients undergo carotid endarterectomy The vulnerable ingredients of carotid plaques such as intraplaque neovascularization and bleeding are identified by pathological examination and immunohistochemical staining
3 To evaluate the accuracy of CEUS for identifying carotid vulnerable plague compared with high resolution MR
4 The investigators divide patients into the stable group and the vulnerable group based on the results of CEUS inspection To analysis the incidence of postoperative complications such as stroke and mortality within 30 days and to compare the differences between the two groups
2 All patients undergo carotid endarterectomy The vulnerable ingredients of carotid plaques such as intraplaque neovascularization and bleeding are identified by pathological examination and immunohistochemical staining
3 To evaluate the accuracy of CEUS for identifying carotid vulnerable plague compared with high resolution MR
4 The investigators divide patients into the stable group and the vulnerable group based on the results of CEUS inspection To analysis the incidence of postoperative complications such as stroke and mortality within 30 days and to compare the differences between the two groups
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None