Ignite Creation Date:
2024-05-05 @ 10:23 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005394
Status:
COMPLETED
Last Update Posted:
2016-05-13
First Post:
2000-05-25
Brief Title:
DiagnosisPathophysiology of Glucocorticoid Remediable Aldosteronism Hypertension
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2004-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To identify and study a large cohort of glucocorticoid remediable aldosteronism GRA patients
Detailed Description:
DESIGN NARRATIVE
The spectrum of the severity and the natural history of the disorder was characterized Modifying environmental and genetic factors important in regulation of blood pressure were determined Also renal physiology was studied in GRA patients to determine how these patients escaped hypokalemia in spite of mineralocorticoid excess There were four specific aims including 1 to determine the natural history and prevalence of GRA in various hypertensive populations 2 to characterize the magnitude of effect imparted on blood pressure by inheritance of GRA and the sources of variation in phenotype expression of the hypertension 3 to investigate the renal and hormonal mechanisms regulating potassium conservation and loss in GRA and 4 to characterize the disequilibrium of GRA with Irish and Scottish descent and specific alleles of the aldosterone synthase gene
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
The spectrum of the severity and the natural history of the disorder was characterized Modifying environmental and genetic factors important in regulation of blood pressure were determined Also renal physiology was studied in GRA patients to determine how these patients escaped hypokalemia in spite of mineralocorticoid excess There were four specific aims including 1 to determine the natural history and prevalence of GRA in various hypertensive populations 2 to characterize the magnitude of effect imparted on blood pressure by inheritance of GRA and the sources of variation in phenotype expression of the hypertension 3 to investigate the renal and hormonal mechanisms regulating potassium conservation and loss in GRA and 4 to characterize the disequilibrium of GRA with Irish and Scottish descent and specific alleles of the aldosterone synthase gene
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL053693 | NIH | None | httpsreporternihgovquickSearchR01HL053693 |