Ignite Creation Date:
2024-05-05 @ 12:03 PM
Last Modification Date:
2024-10-26 @ 9:19 AM
Study NCT ID:
NCT00230165
Status:
RECRUITING
Last Update Posted:
2023-07-06
First Post:
2005-09-28
Brief Title:
The Genetics and Functional Basis of Inherited Platelet White Blood Cell Red Blood Cell and Blood Clotting Disorders
Sponsor:
Rockefeller University
Organization:
Rockefeller University
Study Overview
Official Title:
Studies of Interactions Among Normal and Abnormal Blood Cells and the Vessel Wall and Studies of Genetic and Functional Basis of Inherited Platelet White Blood Cell Red Blood Cell and Coagulation Disorders
Status:
RECRUITING
Status Verified Date:
2023-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Blood contains red blood cells white blood cells and platelets as well as a fluid portion termed plasma We primarily study blood platelets but sometimes we also analyze the blood of patients with red blood cell disorders such as sickle cell disease white blood cell disorders and disorders of the blood clotting factors found in plasma
Blood platelets are small cell fragments that help people stop bleeding after blood vessels are damaged Some individuals have abnormalities in their blood platelets that result in them not functioning properly One such disorder is Glanzmann thrombasthenia Most such patients have a bleeding disorder characterized by nosebleeds gum bleeding easy bruising black and blue marks heavy menstrual periods in women and excessive bleeding after surgery or trauma Our laboratory performs advanced tests of platelet function and platelet biochemistry If we find evidence that a genetic disorder may be responsible we analyze the genetic material DNA and RNA from the volunteer and when possible close family members to identify the precise defect
Blood platelets are small cell fragments that help people stop bleeding after blood vessels are damaged Some individuals have abnormalities in their blood platelets that result in them not functioning properly One such disorder is Glanzmann thrombasthenia Most such patients have a bleeding disorder characterized by nosebleeds gum bleeding easy bruising black and blue marks heavy menstrual periods in women and excessive bleeding after surgery or trauma Our laboratory performs advanced tests of platelet function and platelet biochemistry If we find evidence that a genetic disorder may be responsible we analyze the genetic material DNA and RNA from the volunteer and when possible close family members to identify the precise defect
Detailed Description:
After volunteers and family members agree to participate they are seen in the Outpatient Research Center by the Principal Investigator or another physician A detailed history is obtained a physical examination is performed and blood is obtained for further tests Occasionally patients and family members are requested to return for additional tests If an abnormality is identified with tests conducted in our research laboratory we advise the volunteer to have the studies repeated in a laboratory certified to conduct tests on patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 5R01HL019278-39 | NIH | None | httpsreporternihgovquickSearch5R01HL019278-39 |