Ignite Creation Date:
2024-05-06 @ 8:43 AM
Last Modification Date:
2024-10-26 @ 12:04 PM
Study NCT ID:
NCT02808611
Status:
COMPLETED
Last Update Posted:
2017-06-28
First Post:
2016-06-15
Brief Title:
Influence of Propranolol on Conditioned Pain Modulation
Sponsor:
Kristian Kjær Petersen
Organization:
Aalborg University
Study Overview
Official Title:
Konditionerende Smertestimuli - Sammenligning af Forskellige Test og Konditioneringsmodaliteter
Status:
COMPLETED
Status Verified Date:
2017-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
An extensive amount of studies indicate that conditioned pain modulation CPM test paradigms can be of use to evaluate the efficacy of the endogenous pain inhibition pathway in healthy controls and pain patients A number of studies indicate that the autonomic nervous system ANS responds to painful stimulation by parasympathetic activity withdrawal and up-regulation of sympathetic activity flight-or-fight mode but it remains unknown whether these responses predict individual pain susceptibility or CPM efficacy and whether different pain modalities evoke different physiological stress responses ie do individuals with low pain tolerance exhibit more vigorous ANS responses when subjected to controlled acute pain stimuli and do high ANS responsiveness to pain coincide with altered psychophysical pain levelsCPM efficacy
This study aims to investigate the effect of ANS responsiveness on CPM paradigms and to investigate if an exogenous pharmaceutically induced decrease in the sympathetic drive of the ANS will yield decreased CPM efficacy
This study aims to investigate the effect of ANS responsiveness on CPM paradigms and to investigate if an exogenous pharmaceutically induced decrease in the sympathetic drive of the ANS will yield decreased CPM efficacy
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None