Ignite Creation Date:
2024-05-06 @ 8:38 AM
Last Modification Date:
2024-10-26 @ 12:03 PM
Study NCT ID:
NCT02789943
Status:
UNKNOWN
Last Update Posted:
2017-04-06
First Post:
2016-05-30
Brief Title:
Multi- Level and Integrated Analysis of Mechanisms Underlying Atrial Dysfunction
Sponsor:
National Heart Centre Singapore
Organization:
National Heart Centre Singapore
Study Overview
Official Title:
The National Heart Centre Singapore Prospective CABG Cohort Multi- Level and Integrated Analysis of Mechanisms Underlying Atrial Dysfunction
Status:
UNKNOWN
Status Verified Date:
2016-05
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
STaR-CABG
Brief Summary:
Integrated and cross-disciplinary analysis of human physiology and disease provides unbiased and deeply informative insights into human health and disease In this study the investigators will recruit patients undergoing coronary artery bypass surgery to study the atrium of the heart or the aortic wall that when diseased can cause strokes
Hypothesis Systems-level analysis of the left atrium and aorta cells that integrates imaging histological cellular and molecular data will identify new mechanism for cardiovascular form and function
Hypothesis Systems-level analysis of the left atrium and aorta cells that integrates imaging histological cellular and molecular data will identify new mechanism for cardiovascular form and function
Detailed Description:
While there are many sub-aims to this study the overarching goal is to define molecular mechanisms underlying atrial dysfunction Here the investigator provide a power calculation based on detecting the genetic control points of gene expression eQTLs in the human atrial fibroblast The investigator and many others have shown that tissue-specific eQTLs can be robustly identified at genome-wide significance in segregating populations of 200 In this study the investigator propose eQTL association analysis in humans which have previously been successfully performed in cohorts of less than 1000 subjects The general applicability of this approach has been validated in multiple studies across multiple tissues in cohorts of between 200-1000 subjectsBased on published imaging genetic studies that have been successfully applied in small cohorts 500 and the success of echo-based semi-quantitative studies of ventricular dimensions the investigator are confident that our quantitative studies of 750 individuals are powered to detect genome wide significant loci for the traits under study
Despite intensive research there is a critical gap in our knowledge in the mechanisms underlying atrial fibrillation which is a major cause of stroke and heart failure and increasingly common as it is a disease of the elderly This project will address this important gap in our knowledge and provide new insights into disease pathogenesis with the goal of stratifying participants to prevent strokes and for treating the underlying substrate
Despite intensive research there is a critical gap in our knowledge in the mechanisms underlying atrial fibrillation which is a major cause of stroke and heart failure and increasingly common as it is a disease of the elderly This project will address this important gap in our knowledge and provide new insights into disease pathogenesis with the goal of stratifying participants to prevent strokes and for treating the underlying substrate
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None