Ignite Creation Date:
2024-05-06 @ 8:36 AM
Last Modification Date:
2024-10-26 @ 12:02 PM
Study NCT ID:
NCT02775461
Status:
RECRUITING
Last Update Posted:
2024-01-30
First Post:
2016-05-13
Brief Title:
Pancreas Registry and High Risk Registry
Sponsor:
Icahn School of Medicine at Mount Sinai
Organization:
Icahn School of Medicine at Mount Sinai
Study Overview
Official Title:
Pancreas Disease and High Risk Registry
Status:
RECRUITING
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to establish a registry of patients with pancreatic diseases Patients included in the registry may include those with pancreatic cancer precancerous lesions of the pancreas inflammatory lesions of the pancreas cystic lesions of the pancreas and patients at high-risk of pancreatic cancer such as those with a family history of pancreatic cancer or with a family history of a syndrome known to be associated with pancreatic cancer Pancreatic cancer is the fourth leading cause of death from cancer in the United States However little is known about the development of pancreatic cancer and pancreatic diseases in individuals with the above conditions Knowledge of how family history environmental exposures and inflammatory lesion of the pancreas contribute to the development of pancreatic cancer and pancreatic diseases is essential
You may qualify to take part in this research study because you have inflammation in the pancreas a pancreatic cyst pre-cancerous lesions of the pancreas pancreatic cancer a family history of pancreatic cancer or a family history of a syndrome known to be associated with pancreatic cancer
We will also be collecting a blood sample from all participants for DNA isolation Sometimes we are born with genes or DNA that give us an increased or decreased chance of developing an illness later in life Genetic material will be isolated from your blood for further study You may also choose to provide additional blood samples for serum and plasma extraction Serum and plasma are components of the blood which can be used to measure indicators of disease in the blood called biomarkersfor pancreatic diseases Clinical data and biological specimens contained in this study may be used for a wide variety of future related studies to the cause diagnosis outcome and treatment of pancreatic cancer
Funds for conducting this research are provided by Mount Sinai
You may qualify to take part in this research study because you have inflammation in the pancreas a pancreatic cyst pre-cancerous lesions of the pancreas pancreatic cancer a family history of pancreatic cancer or a family history of a syndrome known to be associated with pancreatic cancer
We will also be collecting a blood sample from all participants for DNA isolation Sometimes we are born with genes or DNA that give us an increased or decreased chance of developing an illness later in life Genetic material will be isolated from your blood for further study You may also choose to provide additional blood samples for serum and plasma extraction Serum and plasma are components of the blood which can be used to measure indicators of disease in the blood called biomarkersfor pancreatic diseases Clinical data and biological specimens contained in this study may be used for a wide variety of future related studies to the cause diagnosis outcome and treatment of pancreatic cancer
Funds for conducting this research are provided by Mount Sinai
Detailed Description:
The overall purpose of this research project is to establish a registry of patients with pancreatic diseases Patients included in the registry may include those with pancreatic cancer precancerous lesions of the pancreas such as intraductal papillary mucinous neoplasms IPMNs and cystic lesions inflammatory lesions and inflammation of the pancreas and patients at high-risk of pancreatic cancer such as those with a family history of pancreatic cancer or with a family history of a syndrome known to be associated with pancreatic cancer The data contained in this registry will be used to conduct research related to the risk of pancreatic cancer and pancreatic diseases As this is a registry protocol no specific hypotheses are to be tested
Specific Aims
1 Establish and maintain a registry of individuals and their family members who have pancreatic diseases and may be at increased risk of developing pancreatic cancer over normal population risk
2 Collect data and review existing data on personal and family histories demographics risk factors and health behaviors
3 Use the data in the registry to conduct studies related to disease risk prevention and prognosis of pancreatic cancer and other pancreatic diseases
Pancreatic cancer is the fourth leading cause of death from malignancy in the United States With near equivalent incidence and mortality cure can only be achieved with surgical resection of an early stage lesion Premalignant disease stages such as IPMN may be detected with noninvasive and minimally invasive techniques providing an opportunity for screening and surveillance of at-risk populations
Knowledge of the etiology of pancreatic cancer is incomplete Approximately 10 of pancreatic ductal adenocarcinoma PDAC has a hereditary component and screening this population has the potential to have an impact on disease mortality Certain patient populations such as those with hereditary pancreatitis Peutz-Jeghers syndrome familial atypical multiple mole melanoma FAMMM syndrome Lynch syndrome and the breast ovarian cancer syndrome BRCA1 and BRCA2 mutations are at the highest risk of PDAC BRCA2 mutations are the most commonly identified germline mutations in families with PDAC Even a family history of PDAC without the above described syndromes has been shown to increase risk suggesting a unique familial pancreatic cancer syndrome which may be related to the partner and localizer of BRCA2 PALB2 gene or other PDAC susceptibility genes Environmental risk factors such as cigarette smoking diabetes obesity and dietary risk factors have been implicated in the development of PDAC
A sequential model of acquisition of somatic mutations via a Pancreatic Intraepithelial Neoplasia PanIN has been proposed for the development of PDAC and subsequent metastases However others have proposed that the metastatic process may be initiated earlier in the disease process during the pre-malignant cyst or PanIN phase This may in part account for the fact that the overwhelming majority of patients diagnosed with PDAC are diagnosed when the lesion is already metastatic
Several groups have instituted PDAC screening for individuals at high-risk of PDAC These groups have demonstrated the feasibility of detection of PDAC and pre-malignant lesions in certain high-risk individuals Given the large gaps in knowledge recruitment of patients with preneoplastic pancreatic diseases to registries is essential in the development of effective PDAC screening and prevention programs
As an increasing number of patients undergo cross-sectional imaging with the abdomen with cat scan CT and magnetic resonance imaging MRI an increasing number of patients are found to have pancreatic disease and pancreatic cysts While there is an increased risk of pancreatic cancer with these lesions the studies to date are small and retrospective
Specific Aims
1 Establish and maintain a registry of individuals and their family members who have pancreatic diseases and may be at increased risk of developing pancreatic cancer over normal population risk
2 Collect data and review existing data on personal and family histories demographics risk factors and health behaviors
3 Use the data in the registry to conduct studies related to disease risk prevention and prognosis of pancreatic cancer and other pancreatic diseases
Pancreatic cancer is the fourth leading cause of death from malignancy in the United States With near equivalent incidence and mortality cure can only be achieved with surgical resection of an early stage lesion Premalignant disease stages such as IPMN may be detected with noninvasive and minimally invasive techniques providing an opportunity for screening and surveillance of at-risk populations
Knowledge of the etiology of pancreatic cancer is incomplete Approximately 10 of pancreatic ductal adenocarcinoma PDAC has a hereditary component and screening this population has the potential to have an impact on disease mortality Certain patient populations such as those with hereditary pancreatitis Peutz-Jeghers syndrome familial atypical multiple mole melanoma FAMMM syndrome Lynch syndrome and the breast ovarian cancer syndrome BRCA1 and BRCA2 mutations are at the highest risk of PDAC BRCA2 mutations are the most commonly identified germline mutations in families with PDAC Even a family history of PDAC without the above described syndromes has been shown to increase risk suggesting a unique familial pancreatic cancer syndrome which may be related to the partner and localizer of BRCA2 PALB2 gene or other PDAC susceptibility genes Environmental risk factors such as cigarette smoking diabetes obesity and dietary risk factors have been implicated in the development of PDAC
A sequential model of acquisition of somatic mutations via a Pancreatic Intraepithelial Neoplasia PanIN has been proposed for the development of PDAC and subsequent metastases However others have proposed that the metastatic process may be initiated earlier in the disease process during the pre-malignant cyst or PanIN phase This may in part account for the fact that the overwhelming majority of patients diagnosed with PDAC are diagnosed when the lesion is already metastatic
Several groups have instituted PDAC screening for individuals at high-risk of PDAC These groups have demonstrated the feasibility of detection of PDAC and pre-malignant lesions in certain high-risk individuals Given the large gaps in knowledge recruitment of patients with preneoplastic pancreatic diseases to registries is essential in the development of effective PDAC screening and prevention programs
As an increasing number of patients undergo cross-sectional imaging with the abdomen with cat scan CT and magnetic resonance imaging MRI an increasing number of patients are found to have pancreatic disease and pancreatic cysts While there is an increased risk of pancreatic cancer with these lesions the studies to date are small and retrospective
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None