Ignite Creation Date:
2024-05-06 @ 8:34 AM
Last Modification Date:
2024-10-26 @ 12:01 PM
Study NCT ID:
NCT02764359
Status:
UNKNOWN
Last Update Posted:
2020-02-05
First Post:
2016-05-02
Brief Title:
Study of Obese Patients Comparing Two Vancomycin Loading Dose Regimens
Sponsor:
CAMC Health System
Organization:
CAMC Health System
Study Overview
Official Title:
Single-Center Prospective Study of Obese Patients Comparing Two Vancomycin Loading Dose Regimens
Status:
UNKNOWN
Status Verified Date:
2020-02
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Obesity alters the movement through the body of several antibiotics including vancomycin Based on literature to date total body weight should be used to determine dosages and shorter dosing intervals may be needed However hospitals have different approaches to managing vancomycin in this patient population The most common example is not exceeding a dose of 2000mg of vancomycin at one time in these patients However some institutions including the Charleston Area Medical Center do not have a set maximum one time dose To date a study has not been done comparing two different dosing regimens in obese patients to determine if having a maximum dose cap is beneficial
This research study is attempting to add to the limited existing body of literature regarding vancomycin dosing in obese patients The investigators hypothesize that optimizing the initial or loading vancomycin dose that obese patients receive will decrease the time to target concentrations For this study obese adult patients will be randomized to receive either 1 a loading dose of 20 mgkg with a maximum dose up to 2000mg OR 2 a loading dose of 20 mgkg with a maximum dose of up to 4000mg The studys primary aim is to determine differences in the time needed to achieve target vancomycin concentrations and the occurrence of adverse events
This research study is attempting to add to the limited existing body of literature regarding vancomycin dosing in obese patients The investigators hypothesize that optimizing the initial or loading vancomycin dose that obese patients receive will decrease the time to target concentrations For this study obese adult patients will be randomized to receive either 1 a loading dose of 20 mgkg with a maximum dose up to 2000mg OR 2 a loading dose of 20 mgkg with a maximum dose of up to 4000mg The studys primary aim is to determine differences in the time needed to achieve target vancomycin concentrations and the occurrence of adverse events
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None