Ignite Creation Date:
2024-05-06 @ 8:33 AM
Last Modification Date:
2024-10-26 @ 12:01 PM
Study NCT ID:
NCT02762708
Status:
COMPLETED
Last Update Posted:
2022-05-03
First Post:
2016-05-03
Brief Title:
The Effect of Bariatric Surgery on Metabolism the Metabolome and Microbiome in Patients With Type 2 Diabetes
Sponsor:
Mayo Clinic
Organization:
Mayo Clinic
Study Overview
Official Title:
The Effect of Bariatric Surgery on Metabolism the Metabolome and the Microbiome in Patients With Type 2 Diabetes
Status:
COMPLETED
Status Verified Date:
2022-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Microbiome
Brief Summary:
What are the benefits of undergoing Roux-en-Y gastric bypass surgery in improving type 2 diabetes outside of weight loss alone
Detailed Description:
Roux-en-y gastric bypass RYGB surgery leads to improvements in diabetes that occurs even before any significant weight loss is seen What are the reasons for this There is evidence in animals that changes in the composition of gut bacteria after RYGB may be responsible for improvements in how glucose is metabolized in the body The study aims to correlate changes in the bacterial composition of the gut that occurs after surgery with improvements in glucose metabolism in people with type 2 diabetes The investigators will do this by using validated methods to measure glucose metabolism and cutting edge technology to analyze the gut microbiome A parallel group of patients with similar weight height and age will undergo caloric restriction alone to mimic weight loss seen after RYGB Participants will also undergo similar glucose metabolism studies and analysis of their gut bacterial composition Thus any difference seen between groups can be attributed to the surgery itself and may lead to identification of novel therapeutic options for diabetes
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None