Ignite Creation Date:
2024-05-05 @ 12:03 PM
Last Modification Date:
2024-10-26 @ 9:19 AM
Study NCT ID:
NCT00223366
Status:
COMPLETED
Last Update Posted:
2020-11-03
First Post:
2005-09-13
Brief Title:
In Vitro Studies on Pharmacological Regulation and Genetic Risk Factors of Peripheral Human Nociceptors
Sponsor:
The University of Texas Health Science Center at San Antonio
Organization:
The University of Texas Health Science Center at San Antonio
Study Overview
Official Title:
Studies on Normal and Inflamed Dental Pulp NPY Regulation of Peripheral Human Nociceptors Peripheral Mechanisms of Opioid Analgesia Cannabinoid-induced Desensitization of TRPV1 Receptors Adrenergic Modulation of Trigeminal Nociceptors
Status:
COMPLETED
Status Verified Date:
2020-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This protocol is for a number of in vitro studies using human surgical biopsies and evaluating the pharmacology and genetics of human nociceptors pain detecting neurons
Detailed Description:
PurposeObjectives
a Specific Aims Specific Aim 1 Characterize in humans the effects of inflammation and neuronal degeneration on peripheral levels of NPY and related Y receptors Y1 Y2 Y5 in periradicular tissue
Specific Aim 2 Determine whether NPY inhibits neurosecretion from peripheral terminals of capsaicin-sensitive neurons innervating normal versus inflamed tissue
Specific Aim 3 Determine whether peripheral administration of NPY is analgesic andor anti-allodynic in patients experiencing spontaneous pain and mechanical allodynia in a clinical model of inflammation with associated neuronal degeneration
Specific Aim 4 Evaluate whether population characteristics are associated with altered pain reports First we will determine whether patients with the C1128 single nucleotide polymorphism SNP of the PreProNPY gene whose phenotype confers substantially augmented peripheral NPY neurosecretion report less pain compared with patients without this genetic polymorphism Second we will determine whether ethniccultural factors associated with an underserved minority population Hispanics in the San Antonio area are associated with altered pain reports
a Specific Aims Specific Aim 1 Characterize in humans the effects of inflammation and neuronal degeneration on peripheral levels of NPY and related Y receptors Y1 Y2 Y5 in periradicular tissue
Specific Aim 2 Determine whether NPY inhibits neurosecretion from peripheral terminals of capsaicin-sensitive neurons innervating normal versus inflamed tissue
Specific Aim 3 Determine whether peripheral administration of NPY is analgesic andor anti-allodynic in patients experiencing spontaneous pain and mechanical allodynia in a clinical model of inflammation with associated neuronal degeneration
Specific Aim 4 Evaluate whether population characteristics are associated with altered pain reports First we will determine whether patients with the C1128 single nucleotide polymorphism SNP of the PreProNPY gene whose phenotype confers substantially augmented peripheral NPY neurosecretion report less pain compared with patients without this genetic polymorphism Second we will determine whether ethniccultural factors associated with an underserved minority population Hispanics in the San Antonio area are associated with altered pain reports
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01NS058655 | NIH | None | httpsreporternihgovquickSearchR01NS058655 |