Ignite Creation Date:
2024-05-05 @ 12:02 PM
Last Modification Date:
2024-10-26 @ 9:19 AM
Study NCT ID:
NCT00229268
Status:
COMPLETED
Last Update Posted:
2012-06-01
First Post:
2005-09-27
Brief Title:
Research on the Nature Diagnosis and Treatment of Obesity and Diabetes
Sponsor:
Rockefeller University
Organization:
Rockefeller University
Study Overview
Official Title:
FOXA2 Expression in Adipose Tissue of Human Subjects With ObesityInsulin-Resistance
Status:
COMPLETED
Status Verified Date:
2012-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine whether the level of FOXA2 expression in fat tissue is a biomarker of insulin resistance To test this hypothesis we will perform euglycemic-hyperinsulinemic clamps in normal and obese human subjects to calculate insulin sensitivity and see if insulin sensitivity correlates with the FOXA2 expression in subcutaneous fat
Detailed Description:
The investigators at Rockefeller University Hospital are engaged in research on the nature diagnosis and treatment of obesity and diabetes The investigators are trying to find out why insulin a blood sugar lowering hormone that is released by the pancreas following a meal does not work effectively in individuals with obesity or type 2 diabetes The investigators have recently discovered a protein in fat cells of obese mice that helps fat cells to take up and break down sugar from the blood This protein called FOXA2 also prevents the generation of more fat cells FOXA2 is only present in obese mice but absent from fat stores of lean animals Insulin can stimulate the production of FOXA2 in fat cells Furthermore the levels of FOXA2 protein correlate with the degree of blood insulin levels In this study we are would like to determine whether FOXA2 is also produced in fat cells of humans and if its level correlates with the degree of obesity and insulin resistance
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None