Ignite Creation Date:
2024-05-06 @ 8:30 AM
Last Modification Date:
2024-10-26 @ 12:01 PM
Study NCT ID:
NCT02759497
Status:
UNKNOWN
Last Update Posted:
2017-06-20
First Post:
2016-05-01
Brief Title:
Evaluation of Serum Amyloid A in Early Diagnosis of Spontaneous Bacterial Peritonitis
Sponsor:
Tanta University
Organization:
Tanta University
Study Overview
Official Title:
Evaluation of Serum Amyloid A in Early Diagnosis of Spontaneous Bacterial Peritonitis
Status:
UNKNOWN
Status Verified Date:
2017-06
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
One of the most common and serious complications in decompensated cirrhotic patients DCPs is bacterial infectionThe most common infections in DCPs are cases of spontaneous bacterial peritonitis SBP which account for 40 70 of cases followed by urinary tract infections pneumonia and cellulitis
Serum amyloid A SAA and C-reactive protein CRP are acute-phase proteins predominantly produced and secreted by hepatocytes Other cells including lymphocytes monocytes and macrophages can also produce these proteins The induction of SAA and CRP synthesis is triggered by a number of cytokines chiefly IL-6 which is released from a variety of cell types but mainly from macrophages and monocytes at inflammatory sites
Serum amyloid A SAA and C-reactive protein CRP are acute-phase proteins predominantly produced and secreted by hepatocytes Other cells including lymphocytes monocytes and macrophages can also produce these proteins The induction of SAA and CRP synthesis is triggered by a number of cytokines chiefly IL-6 which is released from a variety of cell types but mainly from macrophages and monocytes at inflammatory sites
Detailed Description:
Increased serum CRP and SAA levels have been found in a number of disorders including bacterial infections malignancies tissue injuries and tissue rejection Therefore new studies of early diagnosis prevention and treatment are needed to improve clinical outcomes
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None