Ignite Creation Date:
2024-05-06 @ 8:28 AM
Last Modification Date:
2024-10-26 @ 12:00 PM
Study NCT ID:
NCT02747576
Status:
COMPLETED
Last Update Posted:
2021-10-15
First Post:
2016-04-13
Brief Title:
Social Cognition and Brain Integrity in Survivors of Pediatric Medulloblastoma
Sponsor:
St Jude Childrens Research Hospital
Organization:
St Jude Childrens Research Hospital
Study Overview
Official Title:
Social Cognition and Brain Integrity in Survivors of Pediatric Medulloblastoma
Status:
COMPLETED
Status Verified Date:
2021-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Survivors of pediatric medulloblastoma MB are at-risk for neurocognitive and social deficits including specific skills such as facial affect recognition which is the ability to recognize the emotional expressions of another person Because the underlying mechanisms of these deficits are poorly understood the investigators propose to examine social-cognitive skills ie facial affect recognition and indices of brain integrity including an established core neural network of face perception in MB survivors and healthy controls By comparing these outcomes between survivors of MB and healthy controls investigators seek to identify the areas of the brain that help individuals recognize emotions
Primary Objective
To evaluate social cognition in adolescent and young adult survivors of pediatric medulloblastoma
Secondary Objective
To examine indices of brain integrity and function and their association with facial affect recognition in survivors of pediatric medulloblastoma
Primary Objective
To evaluate social cognition in adolescent and young adult survivors of pediatric medulloblastoma
Secondary Objective
To examine indices of brain integrity and function and their association with facial affect recognition in survivors of pediatric medulloblastoma
Detailed Description:
Comprehensive social-cognitive and behavioral data will be collected and structural and functional brain imaging will be completed in an attempt to determine if disruptions to brain integrity and function caused by prior treatment of medulloblastoma directly influence social-cognition and behavior in survivors These outcomes will be compared between survivors and age- gender- and race-matched healthy community controls
Participants who meet eligibility criteria and consent will undergo neurocognitive intelligence attention memory processing speed motor executive function and visuospatial and social cognitive evaluations affect recognition prosody social memory withdrawalisolation loneliness social anxiety visuospatial and executive function Functional magnetic resonance imaging fMRI will be completed during affect identification tasks to assess activation of the core face perception network Magnetic resonance with diffusion tensor imaging DTI will be obtained to quantify water diffusion within white matter tracts to assess white matter integrity and its association with functional outcomes
Participants who meet eligibility criteria and consent will undergo neurocognitive intelligence attention memory processing speed motor executive function and visuospatial and social cognitive evaluations affect recognition prosody social memory withdrawalisolation loneliness social anxiety visuospatial and executive function Functional magnetic resonance imaging fMRI will be completed during affect identification tasks to assess activation of the core face perception network Magnetic resonance with diffusion tensor imaging DTI will be obtained to quantify water diffusion within white matter tracts to assess white matter integrity and its association with functional outcomes
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None