Ignite Creation Date:
2024-05-05 @ 12:02 PM
Last Modification Date:
2024-10-26 @ 9:19 AM
Study NCT ID:
NCT00222781
Status:
COMPLETED
Last Update Posted:
2007-12-19
First Post:
2005-09-19
Brief Title:
Multi-Tracer PET Quantitation of Skeletal Muscle Insulin Resistance in Type 2 Diabetes Mellitus
Sponsor:
University of Pittsburgh
Organization:
University of Pittsburgh
Study Overview
Official Title:
Three-Tracer PET Quantitation of Insulin Action in Muscle
Status:
COMPLETED
Status Verified Date:
2007-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this research is to use a recently developed triple-tracer positron emission tomography PET method to study skeletal muscle insulin resistance Insulin is the hormone made by your body to control the blood sugar level Resistance to insulin could cause poor blood glucose control blood sugar levels that are higher than normal We want to use this new method to image look at the following three things 1 how insulin affects blood flow in skeletal muscle 2 how insulin affects glucose sugar transport movement into muscle and 3 how insulin affects glucose metabolism breakdown in skeletal muscle of healthy individuals
PET imaging is a relatively non-invasive way to obtain a metabolic picture of body organs and has been used successfully to study brain heart and more recently skeletal muscle In this research study we will use PET with three radioactive tracers markers to study skeletal muscle glucose transport in individuals with type 2 diabetes mellitus type 2 DM and in non-diabetic individuals who are either normal weight or overweightobese
PET imaging is a relatively non-invasive way to obtain a metabolic picture of body organs and has been used successfully to study brain heart and more recently skeletal muscle In this research study we will use PET with three radioactive tracers markers to study skeletal muscle glucose transport in individuals with type 2 diabetes mellitus type 2 DM and in non-diabetic individuals who are either normal weight or overweightobese
Detailed Description:
The goal of this proposal is to use a recently developed triple-tracer positron emission tomography PET method to study skeletal muscle insulin resistance IR in research volunteers with type 2 diabetes mellitus type 2 DM and in comparison to age and gender-matched normal weight non-diabetic volunteers and in comparison to age gender and weight-matched overweight or obese non-diabetic volunteers We will use the three tracers to obtain data on the respective insulin actions upon tissue perfusion glucose transport and glucose phosphorylation in order to test the hypothesis that insulin resistance IR in type 2 DM is caused by an aggregation of impairments at these steps thus challenging the prevalent concept that IR derives from a solitary impairment in trans-membrane transport
Proximal steps of glucose transport and phosphorylation are considered to contribute strongly to the pathogenesis of IR in obesity and type 2 DM 1-5 These scientific considerations might have potential therapeutic implications The overall goal of this project is to provide clarity in separating the respective roles of these proximal steps of glucose metabolism Glucose transport will be assessed using 11C-3-O-methyl glucose half-life 20 min also referred to as 3-0-MG an analog that is transported but not phosphorylated 18F-2-deoxy-2-fluoro-glucose half-life 109 min also referred to as FDG will be used to assess glucose transport and glucose phosphorylation The third tracer that will be used 15O-H2O will provide information on tissue perfusion The challenge with the use of FDG to study insulin action in muscle has been to derive data on two biochemical steps from the tissue activity pattern of a single tracer this has placed a higher reliance upon the modeling of the data However in this project because of the use of three tracers and the differences in the metabolism of the two glucose analogs we will be able to address with clear resolution the respective roles of transport and phosphorylation in the pathogenesis of IR in obesity and type 2 DM
Proximal steps of glucose transport and phosphorylation are considered to contribute strongly to the pathogenesis of IR in obesity and type 2 DM 1-5 These scientific considerations might have potential therapeutic implications The overall goal of this project is to provide clarity in separating the respective roles of these proximal steps of glucose metabolism Glucose transport will be assessed using 11C-3-O-methyl glucose half-life 20 min also referred to as 3-0-MG an analog that is transported but not phosphorylated 18F-2-deoxy-2-fluoro-glucose half-life 109 min also referred to as FDG will be used to assess glucose transport and glucose phosphorylation The third tracer that will be used 15O-H2O will provide information on tissue perfusion The challenge with the use of FDG to study insulin action in muscle has been to derive data on two biochemical steps from the tissue activity pattern of a single tracer this has placed a higher reliance upon the modeling of the data However in this project because of the use of three tracers and the differences in the metabolism of the two glucose analogs we will be able to address with clear resolution the respective roles of transport and phosphorylation in the pathogenesis of IR in obesity and type 2 DM
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01DK060555 | NIH | None | httpsreporternihgovquickSearchR01DK060555 |