Ignite Creation Date:
2024-05-06 @ 8:26 AM
Last Modification Date:
2024-10-26 @ 12:00 PM
Study NCT ID:
NCT02733913
Status:
COMPLETED
Last Update Posted:
2017-11-14
First Post:
2016-02-18
Brief Title:
Clinical Impact of Autonomic Modulation After Pulmonary Vein Isolation
Sponsor:
Klinik für Kardiologie Pneumologie und Angiologie
Organization:
Heinrich-Heine University Duesseldorf
Study Overview
Official Title:
Clinical Impact of Autonomic Modulation After Pulmonary Vein Isolation in Patients With Paroxysmal Atrial Fibrillation
Status:
COMPLETED
Status Verified Date:
2017-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Pulmonary vein isolation PVI has become a standard therapy for atrial fibrillation AF however there is still considerable AF recurrence after PVI Except for PV-left atrium LA reconnection the cause of recurrence has been not yet fully clarified
The alternation of autonomic tone plays an important role in initiation of paroxysmal AF It was reported that there are multiple gangliated plexus GP around pulmonary veins therefore the modulation targeting those GPs resulting in modulations of cardiac autonomic tone have been conducted Some study showed the efficacy of GP ablation for AF patients
According to the previous reports heart rate HR increased and heart rate variability HRV reduced after PVI These are considered to be due to autonomic denervation caused by catheter ablation of GP
For the best of investigators knowledge there have been no data on heart rate turbulence HRT of baroreflex sensitivity BRS concerning PVI
The alternation of autonomic tone plays an important role in initiation of paroxysmal AF It was reported that there are multiple gangliated plexus GP around pulmonary veins therefore the modulation targeting those GPs resulting in modulations of cardiac autonomic tone have been conducted Some study showed the efficacy of GP ablation for AF patients
According to the previous reports heart rate HR increased and heart rate variability HRV reduced after PVI These are considered to be due to autonomic denervation caused by catheter ablation of GP
For the best of investigators knowledge there have been no data on heart rate turbulence HRT of baroreflex sensitivity BRS concerning PVI
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None