Ignite Creation Date:
2024-05-06 @ 8:23 AM
Last Modification Date:
2024-10-26 @ 11:59 AM
Study NCT ID:
NCT02721797
Status:
UNKNOWN
Last Update Posted:
2020-03-27
First Post:
2016-03-02
Brief Title:
Origins and Impact of EDS in Connective Tissues and Skin
Sponsor:
University College London
Organization:
University College London
Study Overview
Official Title:
Origins and Impact of EDS in Connective Tissues and Skin
Status:
UNKNOWN
Status Verified Date:
2020-03
Last Known Status:
ENROLLING_BY_INVITATION
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Ehlers-Danlos Syndrome EDS is an inherited disease of collagen found in connective tissues such as skin EDS patients suffer from joint and skin problems skin hyperextensibility joint hypermobility along with a large range of other disorders including delayed wound healing with atrophic scarring easy bruising tissue fragility gastrointestinal and gum problems There are many different types of EDS with different mechanisms of action and not all of these are well understood This study will used advanced microscopy techniques called atomic force microscopy AFM and scanning electron microscopy SEM to analyse the changes in collagen as a result of EDS compared to normal collagen These changes will be viewed at the micron and nanoscale level between 1000 to 100000 x magnification and will focus on the differences in collagen construction through a process called cross-linking These changes could potentially help clinicians understand the root cause of EDS symptoms and provide a deeper knowledge of cross-linking disorders in collagen Increasing our knowledge of how collagen is affected in EDS patients may lead to improved treatment options for patients
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None