Ignite Creation Date:
2024-05-05 @ 12:02 PM
Last Modification Date:
2024-10-26 @ 9:19 AM
Study NCT ID:
NCT00220467
Status:
COMPLETED
Last Update Posted:
2008-07-30
First Post:
2005-09-21
Brief Title:
Cognitive Effects of Aerobic Exercise for MCI Adults
Sponsor:
Seattle Institute for Biomedical and Clinical Research
Organization:
Seattle Institute for Biomedical and Clinical Research
Study Overview
Official Title:
Cognitive Effects of Aerobic Exercise for Adults With Mild Cognitive Impairment A Controlled Trial
Status:
COMPLETED
Status Verified Date:
2008-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The specific aims for the study will be to determine if aerobic exercise enhances cognition for older adults who are at greater risk for developing Alzheimers disease and to evaluate whether change in insulin sensitivity predicts cognitive performance for subjects randomized to the aerobic exercise group Sedentary older adults diagnosed with mild cognitive impairment will participate in a 6-month supervised protocol of either aerobic exercise or stretching Cognitive testing and blood collection will occur at baseline and months 3 and 6 Before and after the 6-month intervention insulin sensitivity maximum aerobic capacity and body fat composition and distribution via CT scan will be assessed for all subjects The results of this study may provide support for a relatively simple and inexpensive treatment strategy that specifically targets many of the health factors that directly influence risk of cognitive decline for older adults
Detailed Description:
The specific aims for the study are 1 to determine if aerobic exercise enhances cognition for older adults with mild cognitive impairment 2 to evaluate whether change in insulin sensitivity predicts cognitive performance for subjects in the aerobic exercise group and 3 to relate exercise effects on insulin sensitivity and cognition to growth factor expression inflammatory markers catecholamines beta-amyloid and body-fat composition Using a randomized controlled parallel group design 40 sedentary older adults diagnosed with mild cognitive impairment will participate in a 6-month supervised protocol of either aerobic exercise or stretching Cognitive testing and blood collection will occur at baseline and months 3 and 6 Before and after the 6-month intervention insulin sensitivity via hyperinsulinemic-euglycemic clamp maximum aerobic capacity via respiratory gas exchange and cardiopulmonary fitness measures and body fat composition via DEXA scan and distribution via CT scan will be assessed for all subjects The results of this study may provide support for a relatively simple and inexpensive treatment strategy that specifically targets many of the health factors that directly influence risk of cognitive decline for older adults
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| ALZ ASSOC BL18 SIBCR | None | None | None |