Ignite Creation Date:
2024-05-05 @ 12:02 PM
Last Modification Date:
2024-10-26 @ 9:19 AM
Study NCT ID:
NCT00219856
Status:
COMPLETED
Last Update Posted:
2012-06-26
First Post:
2005-09-13
Brief Title:
Effects of Propofol on Oxidative Stress and Liver Regeneration After Partial Hepatectomy
Sponsor:
Rennes University Hospital
Organization:
Rennes University Hospital
Study Overview
Official Title:
Prospective Randomized Simple Blind Study Comparing the Effects of an Anaesthesia With Propofol to an Anaesthesia With Desflurane on Oxydative Stress and Liver Function Recovery After Hepatectomy
Status:
COMPLETED
Status Verified Date:
2012-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Propofol is an anaesthetic agent that showed in vitro and in vivo anti oxidant properties No data are available concerning the potential benefit of a total anaesthesia with propofol in partial hepatic surgery Patients who undergo partial hepatic resection have frequent liver insufficiency that could be related in part to the oxidative stress induced by clamping the hepatic vessels during the surgical intervention Our hypothesis is that propofol by increasing liver resistance to this ischemia-reperfusion phenomenon could improve the remaining liver function recovery and therefore could reduce post surgical morbidity
The aim of the study is to evaluate the anti oxidant effects of propofol compared to another widely used anaesthetic agent inhaled desflurane during and after partial hepatic resection with hepatic vessels clamping The primary endpoint will be the level of malondialdehyde a plasmatic marker of oxidative stress 30 minutes after the end of hepatic clamping
The aim of the study is to evaluate the anti oxidant effects of propofol compared to another widely used anaesthetic agent inhaled desflurane during and after partial hepatic resection with hepatic vessels clamping The primary endpoint will be the level of malondialdehyde a plasmatic marker of oxidative stress 30 minutes after the end of hepatic clamping
Detailed Description:
Propofol is an anaesthetic agent that showed in vitro and in vivo anti oxidant properties No data are available concerning the potential benefit of a total anaesthesia with propofol in partial hepatic surgery Patients who undergo partial hepatic resection have frequent liver insufficiency that could be related in part to the oxidative stress induced by clamping the hepatic hilum during the surgical intervention Our hypothesis is that propofol by increasing liver resistance to ischemic-reperfusion injury could improve the remaining liver function recovery and therefore could reduce post surgical morbidity
The aim of the study is to evaluate the anti oxidant effects of propofol compared to another widely used anaesthetic agent inhaled desflurane during and after partial hepatic resection with hepatic hilum clamping
The primary endpoint will be the level of malondialdehyde a plasmatic marker of oxidative stress 30 minutes after the end of hepatic clamping
The evolution over time of other markers of oxidative stress will be studied glutathione myeloperoxidase nitric oxide as well as functional and biological markers of liver regeneration
The aim of the study is to evaluate the anti oxidant effects of propofol compared to another widely used anaesthetic agent inhaled desflurane during and after partial hepatic resection with hepatic hilum clamping
The primary endpoint will be the level of malondialdehyde a plasmatic marker of oxidative stress 30 minutes after the end of hepatic clamping
The evolution over time of other markers of oxidative stress will be studied glutathione myeloperoxidase nitric oxide as well as functional and biological markers of liver regeneration
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| CIC0203026 | Other Identifier | Rennes University Hospital | None |
| PHRC03-02 | OTHER | None | None |