Ignite Creation Date:
2024-05-06 @ 8:13 AM
Last Modification Date:
2024-10-26 @ 11:58 AM
Study NCT ID:
NCT02699008
Status:
COMPLETED
Last Update Posted:
2016-03-04
First Post:
2015-10-30
Brief Title:
High On-treatment Platelet Reactivity Identified by Multiple Platelet Function Assay
Sponsor:
Wuhan Asia Heart Hospital
Organization:
Wuhan Asia Heart Hospital
Study Overview
Official Title:
High On-treatment Platelet Reactivity to Adenosine Diphosphate Identified by Multiple Platelet Function Assay Guide to Modify Anti-platelet Strategy in Patients Undergoing Percutaneous Coronary Intervention
Status:
COMPLETED
Status Verified Date:
2016-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
HOPEmultiPFA
Brief Summary:
High on-treatment platelet reactivity to adenosine diphosphate was a important reason to cause ischemic events in antiplatelet therapy Using single testing to definite HPR may miss the true HPR or over estimate HPR which may lead to randomized trials failed It is not known whether combined multiple platelet function testing could assist to ensuretureHPR and improve clinical outcomes
Detailed Description:
This was a single-center randomized prospective study ACS patients undergoing PCI treated with clopidogrel and aspirin were included in the 3-5th day after prescription of clopidogrel platelet function were tested simultaneously by three methods MPAADP by Light transmittance aggregometryLTA MAADP by Thrombelastography TEG and CTP2Y by Innovance PFA-200 According to three resultTwo of three or all three results higher than cutoff value was identified as HPR MPALTA50MAADP47mmCTP2Y106sPatients was defined as HPRn125 or unHPRn232 HPR patients were divided into HPR-TicagrelorHPR-Tand HPR-ClopidogrelHPR-C randomized HPR-T groupn77 patients antiplatelet agents changed to ticagrelor both unHPR and HPR-C groups keep unchangedClopidogrel The major adverse cardiovascular events MACE were recorded during 1 year Follow-up
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None