Ignite Creation Date:
2024-05-06 @ 8:13 AM
Last Modification Date:
2024-10-26 @ 11:58 AM
Study NCT ID:
NCT02699567
Status:
COMPLETED
Last Update Posted:
2016-03-04
First Post:
2016-02-25
Brief Title:
CD36 and Human Fat Taste Perception
Sponsor:
Washington University School of Medicine
Organization:
Washington University School of Medicine
Study Overview
Official Title:
CD36 Involvement on Fat Taste Perception and Fat Hedonic Value in Humans
Status:
COMPLETED
Status Verified Date:
2016-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
FATYP
Brief Summary:
The purpose of this study is to determine the effect of common human variants in in taste related genes such as CD36 gene a putative fat taste receptor affect fat taste perception
Detailed Description:
At present the general agreement is that humans perceive five taste qualities sweet sour bitter salty and umami the savory meaty taste of some amino acids It is believed that these qualities evolved to help us find nutrients eg sweets umami signaled calories and avoid potential harmful substances eg bitter signalized poison Despite the fact that some fats which can only be obtained through the diet are essential for life fat is not considered a basic taste and the issue of how fats are precisely sensed is unresolved However increasing evidence suggests that in addition to smell and texture taste plays an important role in fat perception Putative fat taste receptor classes have been identified in animal models One such receptor is the glycoprotein CD36 previously documented to be involved in trafficking and storage of fat CD36 was recently found in rodents and humans taste buds In rodents CD36 deletion blunts specifically fat recognition Although CD36 variants are frequent in humans its role in humans fat taste perception and preferences remains incompletely understood and will be the focus of the current proposal The main goal of this study is to determine the effect of a common human variant in the CD36 gene on fat taste perception by using standardized sensory evaluation techniques In addition we will examine whether common variants in taste related genes other than CD36 are associated with individual differences in the perception of flavors of milkshakes prepared with different amounts of fats
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None