Ignite Creation Date:
2024-05-05 @ 12:02 PM
Last Modification Date:
2024-10-26 @ 9:19 AM
Study NCT ID:
NCT00218933
Status:
COMPLETED
Last Update Posted:
2017-02-09
First Post:
2005-09-20
Brief Title:
High-intensity Exercise Training in Patients With Post-infarction Heart Failure
Sponsor:
Norwegian University of Science and Technology
Organization:
Norwegian University of Science and Technology
Study Overview
Official Title:
Anti-remodeling Effect of High-intensity Interval Training in Patients With Post-infarction Heart Failure on Optimal Treatment
Status:
COMPLETED
Status Verified Date:
2017-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Introduction Moderate-intensity endurance-training is known to reduce symptoms increase exercise tolerance and improve quality of life in patients with chronic heart failure The training benefits have mainly been attributed to adaptations in the peripheral circulation and skeletal muscle rather than to adaptations in cardiac performance However attenuation of left ventricular LV remodelling has been documented in some studies The effects of high- vs moderate exercise-intensity on LV-remodelling and endothelial function in patients with post-infarction heart failure are not definitively established and were studied in the present study
Methods Patients with post-infarction heart failure 45-87 yrs 22-males 5-females all received b-blockers and ACE-inhibitors EF 29 peak oxygen uptake 13 mlkgmin were randomized to 12-weeks 2-3 times per week of either moderate exercise-intensity 70 of peak heart rate high-intensity interval-training 95 of peak heart rate or to a control group that received advise from their regular doctors Patients in the two exercise-groups covered similar distance on the treadmill at each exercise-session so that only exercise-intensity differed ie the duration of exercise was longer in the moderate-intensity group Ultrasound was used to assess LV-dimension and function including Tissue Doppler Imaging TDI and endothelial function in the brachial-artery
Methods Patients with post-infarction heart failure 45-87 yrs 22-males 5-females all received b-blockers and ACE-inhibitors EF 29 peak oxygen uptake 13 mlkgmin were randomized to 12-weeks 2-3 times per week of either moderate exercise-intensity 70 of peak heart rate high-intensity interval-training 95 of peak heart rate or to a control group that received advise from their regular doctors Patients in the two exercise-groups covered similar distance on the treadmill at each exercise-session so that only exercise-intensity differed ie the duration of exercise was longer in the moderate-intensity group Ultrasound was used to assess LV-dimension and function including Tissue Doppler Imaging TDI and endothelial function in the brachial-artery
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None