Ignite Creation Date:
2024-05-06 @ 8:05 AM
Last Modification Date:
2024-10-26 @ 11:56 AM
Study NCT ID:
NCT02666976
Status:
COMPLETED
Last Update Posted:
2019-03-22
First Post:
2016-01-24
Brief Title:
The Prospective Study on the Effect of Ilaprazole in Non-erosive Reflux Disease Patients Focused on Histologic Findings and Inflammatory Biomarker
Sponsor:
Yonsei University
Organization:
Yonsei University
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2016-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Non-erosive reflux disease NERD patients used to be less responsive to proton pump inhibitor PPIs as compared with patients with erosive esophagitis The aim of this study is to objectively evaluate the effect of a new PPI ilaprazole in NERD for adjusting the focus of symptom score histopathologic findings and inflammatory biomarker
A prospective study performed at single hospital enrolled 20 patients who were diagnosed clinically as NERD Patients underwent EGD a 24hr-combined multichannel intraluminal impedance and pH esophageal monitoring MII-pH and were treated with ilaprazole 20mg once daily for 4 weeks Biopsies were obtained from 3cm above the EG junction before and after treatment GERD Q questionnaire histologic findings basal cell hyperplasia papillary elongation dilated intercellular spaces intraepithelial eosinophils and intraepithelial T lymphocyte and inflammatory biomarkers TNF-α IL-8 IL-1β TRPV1 and MCP-1 will be accessed
A prospective study performed at single hospital enrolled 20 patients who were diagnosed clinically as NERD Patients underwent EGD a 24hr-combined multichannel intraluminal impedance and pH esophageal monitoring MII-pH and were treated with ilaprazole 20mg once daily for 4 weeks Biopsies were obtained from 3cm above the EG junction before and after treatment GERD Q questionnaire histologic findings basal cell hyperplasia papillary elongation dilated intercellular spaces intraepithelial eosinophils and intraepithelial T lymphocyte and inflammatory biomarkers TNF-α IL-8 IL-1β TRPV1 and MCP-1 will be accessed
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None