Viewing Study NCT00218309



Ignite Creation Date: 2024-05-05 @ 12:01 PM
Last Modification Date: 2024-10-26 @ 9:19 AM
Study NCT ID: NCT00218309
Status: COMPLETED
Last Update Posted: 2017-01-12
First Post: 2005-09-16

Brief Title: Effects of Pre-Session Supplemental Hydromorphone on Drug Seeking Behavior in Opioid Dependent Individuals
Sponsor: National Institute on Drug Abuse NIDA
Organization: National Institute on Drug Abuse NIDA

Study Overview

Official Title: Biobehavioral Studies of Opioid Drug Seeking Behavior Study 1
Status: COMPLETED
Status Verified Date: 2006-05
Last Known Status: None
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: False
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: None
Brief Summary: The purpose of this study is to determine whether the opportunity to take free supplemental hydromorphone HYD influences drug seeking behavior in heroin dependent individuals
Detailed Description: Drug dependence is a condition in which drug seeking holds a higher priority than behaviors controlled by other reinforcers Learning to understand predict and control this maladaptive choice behavior may lead to improved prevention and treatment strategies HYD is a drug currently used as a cough suppressant and to relieve pain The purpose of this study is to determine the extent to which opioid drug seeking behavior in heroin dependent individuals can be reduced by environmental factors including supplemental opioid drug availability drug price and non-drug alternative reinforcers Specifically this study will determine whether pre-session opportunity to take free supplemental HYD influences HYD seeking by using a choice progressive ratio schedule as well as by varying the dose of HYD

Participants in this observational study will undergo multiple test sessions in which they will select between acquiring drug or money Because participants may choose money on all 12 trials of test sessions as a way to avoid receiving an injection a placebo injection will be given when money is chosen Prior to each test session participants will receive a sample of the drug dose During each test session participants will have 12 opportunities to select either drug administered as HYD or money Prior to each individual choice trial participants will receive supplemental HYD Participants will use a computer to earn choices Respiration rate oxygen saturation heart rate and blood pressure will be monitored throughout choice trials Pupil diameter will be measured with a digital camera Participants will complete self-report questionnaires at different times during the study Participants will be maintained on buprenorphine throughout the study with a fixed 3-week detoxification after study completion

Study Oversight

Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
Secondary ID Type Domain Link
R01-15462-1 None None None