Ignite Creation Date:
2024-05-06 @ 8:04 AM
Last Modification Date:
2024-10-26 @ 11:56 AM
Study NCT ID:
NCT02663115
Status:
COMPLETED
Last Update Posted:
2018-06-11
First Post:
2016-01-15
Brief Title:
Influence of Severe Heart Failure to Function and Molecular Biological Parameters of Catabolism in the Human Diaphragm and Peripheral Skeletal Muscle
Sponsor:
Norman Mangner
Organization:
Heart Center Leipzig - University Hospital
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2018-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
LIPAMUS-HF
Brief Summary:
Project aim is to quantify the influence of a severe therapy-refractory heart failure caused by ischemic or dilative myocardiopathy on the function of the diaphragm its molecular biological parameters and on the M vastus lateralis The control group consists of patients with coronary artery disease CAD and normal left ventricular ejection fraction indicated for coronary artery bypass graft surgery CABG Differences in the geneses of heart failure ischemic vs dilative cardiomyopathy will be evaluated during analysis The ubiquitin-proteasome signaling pathway is considered as a central issue for the mechanism of the analyses muscle catabolism
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None