Ignite Creation Date:
2024-05-06 @ 8:04 AM
Last Modification Date:
2024-10-26 @ 11:55 AM
Study NCT ID:
NCT02650102
Status:
UNKNOWN
Last Update Posted:
2016-01-08
First Post:
2016-01-06
Brief Title:
The Role of miR-30 Family Dysregulation in Response to Antipsychotic Treatment
Sponsor:
Shanxi Medical University
Organization:
Shanxi Medical University
Study Overview
Official Title:
The Role of miR-30 Family Dysregulation in Response to Antipsychotic Treatment
Status:
UNKNOWN
Status Verified Date:
2016-01
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aberrant expression of micro-RNAs miRNAs has been described in many human diseases including schizophrenia SZ The previous work has indicated a strong genetic association between the miRNA-30e precursor pre-miR-30e and the risk of SZ However to date few reports have focused on the expression level of the miR-30 family miR-30s and its networks of co-regulation in SZ even in response to antipsychotic treatment Given this the investigator first constructed a hybrid miRNA-TF transcription factor-gene-PPI protein-protein interactions network focusing on miR-30s by bioinformatics technology The investigator then selected several candidate miR-30s and key regulators for further validation These candidates were then quantified by real-time quantitative PCR qRT-PCR in an independent cohort of 200 healthy controls and 200 drug-free SZ patients among which were followed up by 12-week antipsychotic treatment Furthermore the investigator evaluated the correlation between the change in gene expression and the improvement of symptoms
Detailed Description:
Schizophrenia is one of the most serious mental disorderwhich is characterized by high prevalence rate high recurrence rate could increase patients disability and burden of disease But the pathological mechanism is so far unknown Until recently more attention are focused on gene dysregulation hypothesis The preliminary works of our laboratory prompted that microRNA-30e gene polymorphism and expression abnormal may be related to schizophrenia Combined with previous studies showed that miRNA disorder involved in neurodevelopmental obstacle and neuropsychiatric disease the investigators surmised miR-30e dysregulation can impact the occurrence and development of schizophrenia This study will carry on the multidimensional research by using the technology of neurobiology molecular geneticsneuroimaging and so on and integrate methods of molecular cell animal and human body tracking so as to1 Explaining the transcription and regulation mechanisms of target genes of miR-30eand building the gene regulatory network of schizophrenia as the core of miR-30e2To investigate the pathogenesis of miR-30e participate in schizophrenia and to evaluate the clinical value of miR-30e in peripheral blood on the disease diagnose genotyping predicting efficacy and ending The object of this study is to provide new scientific data and research ideas for further exploring the neurobiological basis of schizophrenia and recognize pathophysiological mechanisms of schizophrenia ultimately to improve and strengthen the new situation in schizophrenia prevention
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None