Ignite Creation Date:
2024-05-06 @ 7:59 AM
Last Modification Date:
2024-10-26 @ 11:54 AM
Study NCT ID:
NCT02642068
Status:
COMPLETED
Last Update Posted:
2021-09-02
First Post:
2014-08-25
Brief Title:
Neuropsychology Neuroimage and Neurophysiology in Adults With ADHD
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
Neuropsychology Neuroimage and Neurophysiology in Adults With Attention-Deficit Hyperactivity Disorder An Endophenotype and Follow-up Study
Status:
COMPLETED
Status Verified Date:
2021-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
We anticipate that drug-naïve ADHD probands particularly those with DAT1 or SLC6A2 gene variants may have higher level of altered microstructural integrity of frontostriatal FS frontoparietal FP other hypothesized fiber tracts and decreased brain activity of FS FP and other circuits deficits in ERP and impaired EF SA IIA and VM than probands without DAT1 or SLC6A2 gene variants or adult neurotypical The alterations in the structural and functional connectivity neurophysiological and neuropsychological functioning would be observed in the unaffected siblings as compared to neurotypical The unaffected siblings will be in the intermediate position between drug-naïve adult ADHD probands and neurotypical The genetic dosage is anticipated to pose the strongest effects on the cortical thickness brain volume gyrification and microstructural property of white matter followed by neurophysiology functional connectivity and neuropsychological function with the least effect
In terms of longitudinal follow-up part we also anticipated despite increasing thinning of cortical thickness microstructural integrity of several targets fiber tracts and brain activity of target brain regions and improving performance in EF SA IIV VM from childhood to late adolescence and young adulthood in the neurotypical group the slopes of developmental trajectories of these neuroimaging and neuropsychological function are lower in the ADHD group
In terms of longitudinal follow-up part we also anticipated despite increasing thinning of cortical thickness microstructural integrity of several targets fiber tracts and brain activity of target brain regions and improving performance in EF SA IIV VM from childhood to late adolescence and young adulthood in the neurotypical group the slopes of developmental trajectories of these neuroimaging and neuropsychological function are lower in the ADHD group
Detailed Description:
Attention deficithyperactivity disorder ADHD is a common 3-10 early-onset clinically and genetically heterogeneous neuropsychiatric disorder with lifelong neuropsychological deficits Despite extensive research in adult ADHD in western countries there has been no published data about adult ADHD in Taiwan except the PIs and colleagues previous works on pharmacotherapy in adults with ADHD and only few endophenotype studies based on adults with ADHD in the world The ultimate goals of this 5-year project are to identify which neuropsychological functional and structural connectivity and neurophysiological variables can be effective endophenotypes biomarkers for ADHD based on unaffected sibling 1st-3rd years and follow-up 4th-5th years designs With the accomplishment of the following study goals this study will be the first study on the topics of neuroimaging and neurophysiological endophenotypes on adult ADHD using advanced imaging techniques ie Tract-based autonomic analysis TBAA and comprehensive clinical and neurocognitive data This proposal has one primary aim and four secondary aims
Primary Aim
1 To validate structural assessed by TBAA using diffusing spectrum imaging DSI and functional connectivity assessed by resting-state fMRI in frontostriatal frontoparietal and other circuitries and neurophysiological functions assessed by stop-signal event-related potential ERP N2 P3 ERN Pe as effective imaging endophenotypes by demonstrating the intermediate position of unaffected siblings between ADHD probands and age- sex- handedness- and IQ-matched adult neurotypical and association with DAT1 and NET SLC6A2 variants
Secondary Aims
2 To validate the executive functions EF sustained attention SA intraindividual variability IIV visual-spatial memory VM as effective neurocognitive endophenotypes by demonstrating the intermediate position of unaffected siblings between ADHD probands and adult neurotypical
3 To examine the developmental trajectory and stability of neuropsychological functions and structural and functional connectivity from childhood to adolescence and young adulthood
4 To correlate the data from structural morphometric cortical thickness gyrification fiber tract integrity and functional connectivity rsfMRI neuropsychology Executive function visual-spatial memory sustained attention variability neurophysiology Stop-signal ERP and ADHD core symptoms stratifying by the presence of ADHD presence of DAT1 and NET SLC6A2 variants proband-unaffected sibling dyads and different developmental stages
Primary Aim
1 To validate structural assessed by TBAA using diffusing spectrum imaging DSI and functional connectivity assessed by resting-state fMRI in frontostriatal frontoparietal and other circuitries and neurophysiological functions assessed by stop-signal event-related potential ERP N2 P3 ERN Pe as effective imaging endophenotypes by demonstrating the intermediate position of unaffected siblings between ADHD probands and age- sex- handedness- and IQ-matched adult neurotypical and association with DAT1 and NET SLC6A2 variants
Secondary Aims
2 To validate the executive functions EF sustained attention SA intraindividual variability IIV visual-spatial memory VM as effective neurocognitive endophenotypes by demonstrating the intermediate position of unaffected siblings between ADHD probands and adult neurotypical
3 To examine the developmental trajectory and stability of neuropsychological functions and structural and functional connectivity from childhood to adolescence and young adulthood
4 To correlate the data from structural morphometric cortical thickness gyrification fiber tract integrity and functional connectivity rsfMRI neuropsychology Executive function visual-spatial memory sustained attention variability neurophysiology Stop-signal ERP and ADHD core symptoms stratifying by the presence of ADHD presence of DAT1 and NET SLC6A2 variants proband-unaffected sibling dyads and different developmental stages
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None