Ignite Creation Date:
2024-05-06 @ 7:57 AM
Last Modification Date:
2024-10-26 @ 11:54 AM
Study NCT ID:
NCT02638727
Status:
UNKNOWN
Last Update Posted:
2015-12-23
First Post:
2015-11-08
Brief Title:
Assessment of Short-term Effect of L-Citrulline on Endothelial Function and Vasodilation in Known CAD Patients
Sponsor:
Shahid Beheshti University of Medical Sciences
Organization:
Shahid Beheshti University of Medical Sciences
Study Overview
Official Title:
Assessment of Short-term Effect of L-Citrulline on Endothelial Function and Vasodilation in Known CAD PatientsA Randomized Crossover Clinical Trial
Status:
UNKNOWN
Status Verified Date:
2015-12
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine the efficacy of oral L-Citrulline on endothelial function and vasodilation in patients with coronary artery diseaseCAD by evaluating the brachial artery diameter in the antecubital area by ultrasonography
Detailed Description:
Before prescribing the drug or placebo the patients were evaluated via the ultrasound machine equipped The brachial artery diameter in the antecubital area was measured by the ultrasound and was recorded Then blood pressure cuff was attached on the arm and dilated 50mmhg above the systolic pressure and for 5 minutes remained the same level to induce ischemia at distal tissues until the occurrence of compensatory vasodilatation Then the brachial artery diameter as an estimation of FMD was measured and recorded After 4 minutes of administration of 2 puffs of nitroglycerin spray the brachial artery diameter as an estimation of NMD was measured
After 15 days treatment with the L-Citrulline or the placebo the patients underwent the ultrasonography again and the above assessments were done
Improvement of FMD to NMD ratio before L-Citrulline prescription to FMD to NMD ratio after L-Citrulline prescription is determined as improvement of flow mediated dilation to nitroglycerin dependent vasodilation evaluate
After 15 days treatment with the L-Citrulline or the placebo the patients underwent the ultrasonography again and the above assessments were done
Improvement of FMD to NMD ratio before L-Citrulline prescription to FMD to NMD ratio after L-Citrulline prescription is determined as improvement of flow mediated dilation to nitroglycerin dependent vasodilation evaluate
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None