Ignite Creation Date:
2024-05-06 @ 7:55 AM
Last Modification Date:
2024-10-26 @ 11:53 AM
Study NCT ID:
NCT02621060
Status:
COMPLETED
Last Update Posted:
2019-08-02
First Post:
2015-12-01
Brief Title:
Effect of Chlorogenic Acid on Patients With Impaired Glucose Tolerance
Sponsor:
University of Guadalajara
Organization:
University of Guadalajara
Study Overview
Official Title:
Effect of the Administration of Chlorogenic Acid on Glucemic Control Insulin Secretion and Insulin Sensitivity in Patients With Impaired Glucose Tolerance
Status:
COMPLETED
Status Verified Date:
2019-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Chlorogenic acid has demonstrated promising effects in the treatment of glycemic control obesity dyslipidemia insulin secretion among others The above mentioned findings show that Chlorogenic acid has an excellent potential for the control of glucose as well as insulin secretion and insulin sensitivity
Detailed Description:
A randomized double-blind placebo-controlled clinical trial was carried out in 30 patients with a diagnosis of impaired glucose tolerance in accordance with the American Diabetes Association criteria The patients received 400 mg capsules of Chlorogenic acid or placebo three times daily 1 2 hour before meals for 90 days Before and after intervention the investigators evaluated 2 hours plasma glucose glycated hemoglobin A1C triglycerides high-density lipoprotein fasting glucose and blood pressure body weight body mass index waist circumference total cholesterol low-density lipoprotein very-low-density lipoprotein creatinine aspartate transaminase and alanine transaminase
Were calculated Areas under the curve of glucose and insulin were calculated with de Trapezoidal formula Total insulin secretion was evaluated with the Insulinogenic index and the insulin sensitivity was estimated using the Matsuda index
Were calculated Areas under the curve of glucose and insulin were calculated with de Trapezoidal formula Total insulin secretion was evaluated with the Insulinogenic index and the insulin sensitivity was estimated using the Matsuda index
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None