Ignite Creation Date:
2024-05-06 @ 7:55 AM
Last Modification Date:
2024-10-26 @ 11:53 AM
Study NCT ID:
NCT02624297
Status:
UNKNOWN
Last Update Posted:
2017-05-16
First Post:
2014-03-24
Brief Title:
Chemoreflex Control of Sympathetic Activity in Patients With Coronary Artery Disease
Sponsor:
University of Sao Paulo General Hospital
Organization:
University of Sao Paulo General Hospital
Study Overview
Official Title:
Effect of Exercise Training on Chemoreflex Control of Sympathetic Activity in Patients With Coronary Artery Disease and Obstructive Sleep Apnea
Status:
UNKNOWN
Status Verified Date:
2017-05
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The investigators hypothesize that chemoreflex response of muscle sympathetic nerve activity MSNA during hypoxia and hypercapnia will be increased in coronary artery disease CAD patients and that the presence of obstructive sleep apnea OSA will potentiate these responses And that the exercise training would decrease the chemoreflex response of MSNA in these patients
Detailed Description:
Forty patients with coronary artery disease with n20 and without n20 obstructive sleep apnea will be studied A healthy control age-paired group n10 will be also evaluated The patients will be submitted to a polysomnography and randomized for clinical follow-up or exercise training for four months It will evaluated the autonomic function chemoreflex control of sympathetic activity during hypoxic and hypercapnic maneuvers endothelial function and inflammatory markers
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None