Ignite Creation Date:
2024-05-05 @ 12:01 PM
Last Modification Date:
2024-10-26 @ 9:19 AM
Study NCT ID:
NCT00218361
Status:
COMPLETED
Last Update Posted:
2012-06-05
First Post:
2005-09-16
Brief Title:
Effects of Post-Session Supplemental Hydromorphone on Drug Seeking Behavior in Opioid Dependent Individuals
Sponsor:
Wayne State University
Organization:
Wayne State University
Study Overview
Official Title:
Biobehavioral Study of Opioid Drug Seeking Behavior Study 2
Status:
COMPLETED
Status Verified Date:
2012-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine whether knowledge of post-session hydromorphone HYD availability reduces drug seeking behavior in heroin dependent individuals
Detailed Description:
Drug dependence is often characterized by severe drug seeking behavior Learning to understand predict and control this maladaptive choice behavior may lead to improved prevention and treatment strategies HYD is a drug that is currently used as a cough suppressant and to relieve pain The purpose of this study is to determine the extent to which opioid drug seeking behavior by heroin dependent individuals can be reduced by environmental factors including supplemental opioid drug availability drug price and alternative non-drug reinforcers Specifically this study will determine whether knowledge of post-session HYD availability influences drug seeking behavior in heroin dependent individuals who are maintained on buprenorphine during their participation
Participants in this observational study will take part in multiple trials in which they have the opportunity to choose either HYD or money On the first two experimental days prior to choice sessions participants will receive a sample of the drug doses that can be chosen During test sessions participants will have 12 opportunities to choose either drug or money Participants will use a computer to earn choices Respiration rate oxygen saturation heart rate and blood pressure will be monitored throughout choice trials Supplemental HYD will be made available following some choice sessions Self-report questionnaires will be completed at different times during the study Participants will be maintained on buprenorphine throughout the study with a minimum 2-week lead before the experiment and a fixed 3-week detoxification after study completion
Participants in this observational study will take part in multiple trials in which they have the opportunity to choose either HYD or money On the first two experimental days prior to choice sessions participants will receive a sample of the drug doses that can be chosen During test sessions participants will have 12 opportunities to choose either drug or money Participants will use a computer to earn choices Respiration rate oxygen saturation heart rate and blood pressure will be monitored throughout choice trials Supplemental HYD will be made available following some choice sessions Self-report questionnaires will be completed at different times during the study Participants will be maintained on buprenorphine throughout the study with a minimum 2-week lead before the experiment and a fixed 3-week detoxification after study completion
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01DA015462 | NIH | None | None |
| R01-15462-2 | None | None | None |
| DPMC | US NIH GrantContract | None | httpsreporternihgovquickSearchR01DA015462 |