Ignite Creation Date:
2024-05-06 @ 7:52 AM
Last Modification Date:
2024-10-26 @ 11:53 AM
Study NCT ID:
NCT02614807
Status:
WITHDRAWN
Last Update Posted:
2018-09-10
First Post:
2015-10-21
Brief Title:
Protein Supplementation in Thiazide-induced Hyponatremia
Sponsor:
Ottawa Hospital Research Institute
Organization:
Ottawa Hospital Research Institute
Study Overview
Official Title:
Thiazide Diuretic-caused Hyponatremia in the Elderly Hypertensive Will a Bottle of Nepro a Day Keep Hyponatremia and the Doctor Away A Proof-of-Concept Trial
Status:
WITHDRAWN
Status Verified Date:
2018-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Difficult Recruitment
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
High blood pressure is very common among elderly Canadians Clinical trials show clear benefit from lowering blood pressure in hypertensive elderly patients These trials also demonstrate safety for several classes of blood pressure lowering drugs including water pills However water pills thiazide diuretics used for treatment of hypertension can cause low sodium hyponatremia a significant clinical problem mainly among elderly and very elderly Causes are age related decrease in kidneys ability to get rid of water and low salt coupled with high water intake A standard approach to treatment is lacking since higher salt intake may worsen hypertension and lower water and higher protein intake is difficult to understand and actually implement Nepro is a nutritional drink high in protein and low in potassium and sodium It is used frequently as a dietary supplement in patients with kidney disease specifically for low sodium and high protein content The high protein content in Nepro can help the kidney get rid of excess water and the low sodium and potassium content will make this a safe option to use Hence investigators propose a proof-of-concept trial on an easy to understand and administer and relatively affordable solution to this issue It could be summarized in one sentence Will a bottle of Nepro a day keep thiazide-caused hyponatremia and the doctor away
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None