Ignite Creation Date:
2024-05-06 @ 7:51 AM
Last Modification Date:
2024-10-26 @ 11:53 AM
Study NCT ID:
NCT02613026
Status:
COMPLETED
Last Update Posted:
2015-11-24
First Post:
2015-11-03
Brief Title:
Comparative Analysis of the Efficacies in Neoadjuvant Chemotherapy of Breast Cancer
Sponsor:
307 Hospital of PLA
Organization:
307 Hospital of PLA
Study Overview
Official Title:
Comparative Analysis of the Efficacies of AT and AC-T Regimens in Neoadjuvant Chemotherapy of Breast Cancer
Status:
COMPLETED
Status Verified Date:
2015-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to compare the short-term and long-term efficacies and the safeties of pirarubicin plus docetaxelAT group and pirarubicin plus cyclophosphamide followed by docetaxelAC-T group in neoadjuvant chemotherapy of breast cancer
Detailed Description:
Based on the results of NSABPNational Surgical Adjuvant Breast and Bowel Project B27 trial anthracyclinesA and TaxanesT are most commonly recommended in neoadjuvant chemotherapy of breast cancer
Pirarubicin is one of anthracyclines and by embedding the DNA double stranded which inhibits DNA replication and RNA synthesis thereby impedes the rapid growth of cancer cells
Docetaxel in one of taxanes and by strengthening the tubulin polymerization inhibiting of microtubule depolymerization and leading to the formation of stable non functional microtubule bundles which destroys mitosis of tumor cells
Pirarubicin is one of anthracyclines and by embedding the DNA double stranded which inhibits DNA replication and RNA synthesis thereby impedes the rapid growth of cancer cells
Docetaxel in one of taxanes and by strengthening the tubulin polymerization inhibiting of microtubule depolymerization and leading to the formation of stable non functional microtubule bundles which destroys mitosis of tumor cells
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None