Ignite Creation Date:
2024-05-05 @ 12:00 PM
Last Modification Date:
2024-10-26 @ 9:18 AM
Study NCT ID:
NCT00200876
Status:
COMPLETED
Last Update Posted:
2017-03-24
First Post:
2005-09-13
Brief Title:
Effects of Anticipation of Pain Relief on Brain Mechanisms
Sponsor:
University of Michigan
Organization:
University of Michigan
Study Overview
Official Title:
Neurochemical Mediation of Placebo Responses in Humans
Status:
COMPLETED
Status Verified Date:
2017-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will use brain imaging technology to examine chemical systems in the brain that suppress pain and stress when an individual has an expectation of pain relief
Detailed Description:
Evidence suggests that the expectation of pain relief even if a person receives only a placebo can provide actual therapeutic benefits The µ-opioid receptor system located in the brain is activated during anticipation of pain relief this activation suppresses stress and pain responses This study will use brain imaging technology to examine the effects of a placebo intervention on µ-opioid neurotransmitters Examination of the factors that regulate these placebo-activated neurotransmitter responses will clarify the overall neurobiology underlying variations in the responses to placebos as well as pain and other stressful conditions ultimately leading to the optimization of medical and psychological interventions
This study will last several hours during one study visit Participants will receive both a painful and a painless injection while undergoing positron emission tomography PET brain imaging The painful injection will consist of small amounts of hypertoninc saline concentrated saline that causes cell shrinkage in the jaw muscle over a 20-minute period Several minutes after participants receive hypertonic saline they will receive an injection with isotonic saline not associated with pain in the opposite jaw muscle After participants receive the injections they will either be told or not be told about a pain relief intervention PET imaging will continue as participants either anticipate or do not anticipate pain relief Participants will be asked about their pain levels repeatedly throughout the study their responses will be entered into a computer-controlled system which will modulate rates of saline infusion
This study will last several hours during one study visit Participants will receive both a painful and a painless injection while undergoing positron emission tomography PET brain imaging The painful injection will consist of small amounts of hypertoninc saline concentrated saline that causes cell shrinkage in the jaw muscle over a 20-minute period Several minutes after participants receive hypertonic saline they will receive an injection with isotonic saline not associated with pain in the opposite jaw muscle After participants receive the injections they will either be told or not be told about a pain relief intervention PET imaging will continue as participants either anticipate or do not anticipate pain relief Participants will be asked about their pain levels repeatedly throughout the study their responses will be entered into a computer-controlled system which will modulate rates of saline infusion
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01AT001415-01A1 | NIH | None | httpsreporternihgovquickSearchR01AT001415-01A1 |