Ignite Creation Date:
2024-05-05 @ 12:00 PM
Last Modification Date:
2024-10-26 @ 9:18 AM
Study NCT ID:
NCT00203684
Status:
UNKNOWN
Last Update Posted:
2017-02-17
First Post:
2005-09-13
Brief Title:
Mentored Patient-Oriented Research Career Development Award
Sponsor:
University of California Los Angeles
Organization:
University of California Los Angeles
Study Overview
Official Title:
The Effects of Different Sized Inhaled Corticosteroids on Peripheral Lung Inflammation in Asthma Assessed Through Lung Tissue Samples SMART Protocol
Status:
UNKNOWN
Status Verified Date:
2017-02
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Asthmatics have inflammation in the large airways tubes through which air travels in and out of the lungs The large airways are located in the central lung New research shows that asthmatics also have inflammation in the small airways The small airways are located in the peripheral lung the parts of the lung away from the central lung
Until now most of the inhaled medications available have been made up of big particles that never reach the peripheral lung The purpose of this study is to try to measure the level of inflammation in the peripheral lung in asthmatics and see if this inflammation can be decreased with different types of inhaled corticosteroids The investigators will check airway inflammation before and after use of an inhaled corticosteroid that has a large particle size and should only reach the large airways Flunisolide-CFC and before and after use of an inhaled small particle corticosteroid that should reach both the large and small airways Flunisolide-HFA
Subjects will make 6 study visits over two phases of the study In the first phase the investigators will collect baseline information about subjects while they are using placebo inactive substance In the second phase subjects will take either the large or small particle corticosteroid
Visits will involve questionnaires and various tests measuring lung function such as spirometry forced oscillation and methacholine challenge Exhaled nitric oxide will be measured as an indication of inflammation Subjects will also measure and make note of lung function at home twice daily using a peak expiratory flow meter Two of the visits will involve fiberoptic bronchoscopy so that the investigators may collect cells and tissue samples without surgery Another two of the visits will involve the use of high resolution computed tomography HRCT scans to indirectly evaluate disease in distant parts of the lungs
Until now most of the inhaled medications available have been made up of big particles that never reach the peripheral lung The purpose of this study is to try to measure the level of inflammation in the peripheral lung in asthmatics and see if this inflammation can be decreased with different types of inhaled corticosteroids The investigators will check airway inflammation before and after use of an inhaled corticosteroid that has a large particle size and should only reach the large airways Flunisolide-CFC and before and after use of an inhaled small particle corticosteroid that should reach both the large and small airways Flunisolide-HFA
Subjects will make 6 study visits over two phases of the study In the first phase the investigators will collect baseline information about subjects while they are using placebo inactive substance In the second phase subjects will take either the large or small particle corticosteroid
Visits will involve questionnaires and various tests measuring lung function such as spirometry forced oscillation and methacholine challenge Exhaled nitric oxide will be measured as an indication of inflammation Subjects will also measure and make note of lung function at home twice daily using a peak expiratory flow meter Two of the visits will involve fiberoptic bronchoscopy so that the investigators may collect cells and tissue samples without surgery Another two of the visits will involve the use of high resolution computed tomography HRCT scans to indirectly evaluate disease in distant parts of the lungs
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NIH grant 5K23RR018538-03 | None | None | None |