Ignite Creation Date:
2024-05-06 @ 7:45 AM
Last Modification Date:
2024-10-26 @ 11:52 AM
Study NCT ID:
NCT02599415
Status:
COMPLETED
Last Update Posted:
2016-03-25
First Post:
2015-03-06
Brief Title:
Anti-psoriatic Effect of TL01 Light Therapy
Sponsor:
University of Aberdeen
Organization:
University of Aberdeen
Study Overview
Official Title:
Studying the Effect of Narrow Band Ultraviolet B Phototherapy on Skin Dendritic DCs Cells in Psoriasis Patients
Status:
COMPLETED
Status Verified Date:
2016-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This is a pilot study to investigate the effect of TL01 narrow band UVB therapy on the resident dermal dendritic cells characterized by expression of CD1c and CD141 These cells were reported to have a role in induction of tolerogenic regulatory T cells and production of IL-10 The investigators proposed to investigate the effect of NB-UVB on these subsets of cells after two weeks of treatment to provide better understanding of the mechanism of action of light treatment
Detailed Description:
Six patients with plaque psoriasis were recruited from the phototherapy unit These patients were referred by their dermatologist to receive narrow-band UVB TL01 light treatment Two 6 mm lesional skin punch biopsies were taken at baseline and 2 weeks after commencing the light treatment to study the effect of light on innate immune cells involved in psoriasis pathogenesis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None