Ignite Creation Date:
2024-05-06 @ 7:43 AM
Last Modification Date:
2024-10-26 @ 11:51 AM
Study NCT ID:
NCT02585349
Status:
COMPLETED
Last Update Posted:
2022-08-26
First Post:
2014-12-11
Brief Title:
Cognition and Affect After Stroke a Prospective Evaluation of Risks
Sponsor:
Maastricht University Medical Center
Organization:
Maastricht University Medical Center
Study Overview
Official Title:
Cognition and Affect After Stroke a Prospective Evaluation of Risks
Status:
COMPLETED
Status Verified Date:
2022-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
CASPER
Brief Summary:
Stroke is a leading cause of disability affecting about 34000 to 41000 individuals in the Netherlands of middle and old age every year Due to the aging of the population this figure will increase considerably over the next decades Struijs et al 2005 Twenty-five percent of stroke patients die within one month making stroke a major risk factor for premature death in developed countries According to the World Health Organization stroke is the third leading cause of the burden of disease in middle and high-income countries World Health Organization 2008 It has a significant negative impact on quality of life of both the patients as well as their caregivers and significant others Surviving stroke patients often struggle with its manifold and lifelong lasting consequences with 35 percent of patients being functionally dependent one year after stroke Wolfe 2000 and cognitive and emotional changes which are found up to two years post-stroke Rasquin Lodder Verhey 2005 Depression apathy and cognitive impairment are very prevalent and significantly contribute to the burden of the disease but their etiologies remain poorly understood
The aim of the CASPER study is to gain more insight into the etiologies of post-stroke depression PSD post-stroke apathy PSA vascular cognitive impairment VCI and post-stroke dementia Therefore the primary objectives are to identify biomarker-based predictors of PSD PSA and VCI A secondary aim is to study effect modulation especially the interaction between cerebrovascular disease neurodegenerative changes and inflammation in post-stroke dementia
CASPER is a prospective clinical cohort study of 250 first-ever ischemic stroke patients with serial assessments at baseline 10 to 12 weeks after stroke six and 12 months after baseline Another wave 36 month after baseline was later added
The aim of the CASPER study is to gain more insight into the etiologies of post-stroke depression PSD post-stroke apathy PSA vascular cognitive impairment VCI and post-stroke dementia Therefore the primary objectives are to identify biomarker-based predictors of PSD PSA and VCI A secondary aim is to study effect modulation especially the interaction between cerebrovascular disease neurodegenerative changes and inflammation in post-stroke dementia
CASPER is a prospective clinical cohort study of 250 first-ever ischemic stroke patients with serial assessments at baseline 10 to 12 weeks after stroke six and 12 months after baseline Another wave 36 month after baseline was later added
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None