Viewing Study NCT02588781



Ignite Creation Date: 2024-05-06 @ 7:41 AM
Last Modification Date: 2024-10-26 @ 11:51 AM
Study NCT ID: NCT02588781
Status: UNKNOWN
Last Update Posted: 2022-06-15
First Post: 2015-10-27

Brief Title: Pemetrexed Alone as Salvage Treatment in Metastatic Colorectal Cancer Patients Who Were Failed After Standard Chemotherapy A Phase II Single Arm Prospective Study
Sponsor: Samsung Medical Center
Organization: Samsung Medical Center

Study Overview

Official Title: Pemetrexed Alone as Salvage Treatment in Metastatic Colorectal Cancer Patients Who Were Failed After Standard Chemotherapy A Phase II Single Arm Prospective Study
Status: UNKNOWN
Status Verified Date: 2022-06
Last Known Status: ACTIVE_NOT_RECRUITING
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: False
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: None
Brief Summary: Pemetrexed is an anticancer agent that exerts its action by disrupting crucial folate-dependent metabolic processes essential for cell replication In vitro studies have shown that pemetrexed behaves as a multitargeted antifolate by inhibiting thymidylate synthase TS dihydrofolate reductase DHFR and glycinamide ribonucleotide formyltransferase GARFT which are key folate-dependent enzymes for the de novo biosynthesis of thymidine and purine nucleotidesPemetrexed is used as a standard therapeutic agent for lung cancer pleural mesothelioma peritoneal mesotheliomaIn addition to these effective anti-cancer effect Pemetrexed is not severe side effects of the medicine

Pemetrexed has been research in colon cancer Zhang etc demonstrated the anti-cancer effect of Pemetrexed in human colon cancer Cells

Although sometimes made also two or more clinical studies Pemetrexed was reported 15-17 of the treatment response rate in these two studies
Detailed Description: None

Study Oversight

Has Oversight DMC: None
Is a FDA Regulated Drug?: None
Is a FDA Regulated Device?: None
Is an Unapproved Device?: None
Is a PPSD?: None
Is a US Export?: None
Is an FDA AA801 Violation?: None