Ignite Creation Date:
2024-05-06 @ 7:41 AM
Last Modification Date:
2024-10-26 @ 11:51 AM
Study NCT ID:
NCT02588781
Status:
UNKNOWN
Last Update Posted:
2022-06-15
First Post:
2015-10-27
Brief Title:
Pemetrexed Alone as Salvage Treatment in Metastatic Colorectal Cancer Patients Who Were Failed After Standard Chemotherapy A Phase II Single Arm Prospective Study
Sponsor:
Samsung Medical Center
Organization:
Samsung Medical Center
Study Overview
Official Title:
Pemetrexed Alone as Salvage Treatment in Metastatic Colorectal Cancer Patients Who Were Failed After Standard Chemotherapy A Phase II Single Arm Prospective Study
Status:
UNKNOWN
Status Verified Date:
2022-06
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Pemetrexed is an anticancer agent that exerts its action by disrupting crucial folate-dependent metabolic processes essential for cell replication In vitro studies have shown that pemetrexed behaves as a multitargeted antifolate by inhibiting thymidylate synthase TS dihydrofolate reductase DHFR and glycinamide ribonucleotide formyltransferase GARFT which are key folate-dependent enzymes for the de novo biosynthesis of thymidine and purine nucleotidesPemetrexed is used as a standard therapeutic agent for lung cancer pleural mesothelioma peritoneal mesotheliomaIn addition to these effective anti-cancer effect Pemetrexed is not severe side effects of the medicine
Pemetrexed has been research in colon cancer Zhang etc demonstrated the anti-cancer effect of Pemetrexed in human colon cancer Cells
Although sometimes made also two or more clinical studies Pemetrexed was reported 15-17 of the treatment response rate in these two studies
Pemetrexed has been research in colon cancer Zhang etc demonstrated the anti-cancer effect of Pemetrexed in human colon cancer Cells
Although sometimes made also two or more clinical studies Pemetrexed was reported 15-17 of the treatment response rate in these two studies
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None