Ignite Creation Date:
2024-05-06 @ 7:40 AM
Last Modification Date:
2024-10-26 @ 11:50 AM
Study NCT ID:
NCT02575521
Status:
COMPLETED
Last Update Posted:
2017-11-08
First Post:
2015-10-07
Brief Title:
Effect of Propofol-Dexmedetomidine on Cerebral Oxygenation and Metabolism During Brain Tumor Resection
Sponsor:
Mansoura University
Organization:
Mansoura University
Study Overview
Official Title:
Effect of Propofol-Dexmedetomidine Total Intravenous Anaesthesia on Cerebral Oxygenation and Metabolism During Brain Tumor Resection Compared to Sevoflurane Anaesthesia
Status:
COMPLETED
Status Verified Date:
2017-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Despite theoretical benefits of intravenous agents volatile agents remain popular In a study comparing desflurane isoflurane and sevoflurane in a porcine model of intracranial hypertension at equipotent doses and normocapnia cerebral blood flow CBF and intra-cranial pressure ICP were least with sevoflurane
Propofol is the most commonly used intravenous anesthetic It has many theoretical advantages by reducing cerebral blood volume CBV and ICP and preserving both autoregulation and vascular reactivity Neurosurgical patients anaesthetized with propofol were found to have lower ICP and higher CPP than those anaesthetized with isoflurane or sevoflurane
The well known pharmacodynamic advantages of intravenous anesthetics may give this group of drugs superior cerebral effects when compared with inhalation anesthetics
Propofol is the most commonly used intravenous anesthetic It has many theoretical advantages by reducing cerebral blood volume CBV and ICP and preserving both autoregulation and vascular reactivity Neurosurgical patients anaesthetized with propofol were found to have lower ICP and higher CPP than those anaesthetized with isoflurane or sevoflurane
The well known pharmacodynamic advantages of intravenous anesthetics may give this group of drugs superior cerebral effects when compared with inhalation anesthetics
Detailed Description:
The aim of this study is to evaluate the cerebral haemodaynamics and global cerebral oxygenation as well as the systemic haemodaynamic changes using dexmedetomidine propofol and fentanyl as total intravenous anaesthestics TIVA in comparison with sevoflurane - fentanyl anesthesia in brain tumor resection
Indicators of global cerebral oxygenation and haemodynamics will be calculated using jugular bulb and peripheral arterial blood sampling
Induction propofol 15 - 2 mgkg
Muscle Relaxants atracurium 05 mgkg with induction and 01 mgkg20min for maintenance
Cannulation Arterial cannula under complete aseptic conditions 20G cannula was inserted into the radial artery of non dominant hand after performing modified Allens test and local infiltration of 05ml xylocaine 2
Central venous catheter A suitable central venous catheter will be inserted into Rt subclavian vein under complete aseptic technique its correct position will be confirmed with chest X-Ray
Jugular bulb catheterization Under strict sterile technique the right internal jugular vein will be cannulated in a retrograde technique with confirmation of the catheter tip position using X-Ray C- arm Puncture site will be at the level of cricoid cartilage behind the anterior border of the sternocleido-mastoid muscle
Indicators of global cerebral oxygenation and haemodynamics will be calculated using jugular bulb and peripheral arterial blood sampling
Induction propofol 15 - 2 mgkg
Muscle Relaxants atracurium 05 mgkg with induction and 01 mgkg20min for maintenance
Cannulation Arterial cannula under complete aseptic conditions 20G cannula was inserted into the radial artery of non dominant hand after performing modified Allens test and local infiltration of 05ml xylocaine 2
Central venous catheter A suitable central venous catheter will be inserted into Rt subclavian vein under complete aseptic technique its correct position will be confirmed with chest X-Ray
Jugular bulb catheterization Under strict sterile technique the right internal jugular vein will be cannulated in a retrograde technique with confirmation of the catheter tip position using X-Ray C- arm Puncture site will be at the level of cricoid cartilage behind the anterior border of the sternocleido-mastoid muscle
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None