Ignite Creation Date:
2024-05-06 @ 7:40 AM
Last Modification Date:
2024-10-26 @ 11:51 AM
Study NCT ID:
NCT02577848
Status:
UNKNOWN
Last Update Posted:
2015-10-19
First Post:
2015-10-15
Brief Title:
GLP-1 on Non-ST-Segment Elevation Myocardial Infarction
Sponsor:
Chinese PLA General Hospital
Organization:
Chinese PLA General Hospital
Study Overview
Official Title:
Effects of Liraglutide on Left Ventricular Function in Patients With Non-ST-Segment Elevation Myocardial Infarction
Status:
UNKNOWN
Status Verified Date:
2015-10
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The investigators planned to evaluate the effects of liraglutide on left ventricular function in patients with non-ST-segment elevation myocardial infarction NSTEMI
Detailed Description:
Patients with non-ST-segment elevation myocardial infarction NSTEMI are a heterogeneous group with respect to the risk of having a major adverse cardiac event MACE Elevation of blood glucose is a common metabolic disorder among patients with acute myocardial infarction AMI and is associated with adverse prognosis Glucagon-like peptide-1 GLP-1 is an incretin hormone that regulates plasma glucose GLP-1 analogues have significant cardiovascular protective effects in patients with AMI GLP-1 may have antioxidant and anti-inflammatory properties and protect endothelial function Studies in conscious chronically instrumented dogs demonstrated that GLP-1 infusion increases insulin sensitivity and myocardial glucose uptake in postischemic contractile dysfunction and dilated cardiomyopathy Liraglutide a GLP-1 analogue was reported to reduce cardiac rupture and infarct size and improve cardiac output in normal and diabetic mice Continuous infusion of GLP-1 15 pmolkgmin has been shown to improve functional recovery in patients with AMI complicated by decreased left ventricular function GLP-1 could protect against ischemia-reperfusion injury and improve cardiac function in patients with acute ST-segment elevation myocardial infarction However the effects of GLP-1 on NSTEMI patients remain unclear The aim of this study was to evaluate the effects of liraglutide on left ventricular function in patients with NSTEMI
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None