Ignite Creation Date:
2024-05-06 @ 7:39 AM
Last Modification Date:
2024-10-26 @ 11:51 AM
Study NCT ID:
NCT02579590
Status:
COMPLETED
Last Update Posted:
2019-02-26
First Post:
2015-10-15
Brief Title:
The Female Sexual Functions With Progestogen-only Contraception
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Evaluation of Female Sexual Functions in Progestogen-only Contraceptive Users
Status:
COMPLETED
Status Verified Date:
2019-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Female sexual dysfunction is age-related progressive and very common condition The physiology of the female sexual function is a complex condition affected by emotional medical and hormonal elements
Progestogen-only contraception relies on progestogens alone to achieve contraception There are several progestogen only contraceptive methods include progestogen only pill minipill subdermal implants Depo-Provera DMPA and levonorgestrel intrauterine system Many studies in literature reported the negative effect of combined oral contraceptive pills COCs on female sexual function due to decrease in bioavailability of testosterone and increase level of sex hormone binding globulin SHBG which leads to decrease in free testosterone level contributes to dysfunction
However the progesterone only methods contains no estrogen so it has less effect on sex hormone binding globulin and therefore less effect on free testosterone DMPA injectable progestins is an injectable progestin is a highly reliable form of contraception Nelson in 1996 found that about 6 of women using DMPA reported either lost or decreased libido More recent study by Fortenberry in 2011 reported that DMPA had no effect on sexual interest compared with nonusers of any hormonal method of contraception in an adolescent population The etonogestrel implant Implanon is a single rod that is inserted into the medial side of non dominant upper arm Although in general it is very effective and has relatively low side effect a decreased libido has been noted
Cerazette is a progestogen-only contraceptive pill containing 75 micrograms of desogestrel It acts mainly by inhibiting ovulation Cerazette users also may complain of decreased libido
The estrogen is the main hormone which responsible for vitality of the pelvic organ especially the vagina The main mechanism of action of the DMPA Implanon and Cerazette is inhibition of ovulation which leads to decrease in the estrogen level which causes a drop in blood flow in uterine artery and accordingly the vagina artery That can affect vaginal lubrication causing the vagina to be too dry for comfortable sex
Progestogen-only contraception relies on progestogens alone to achieve contraception There are several progestogen only contraceptive methods include progestogen only pill minipill subdermal implants Depo-Provera DMPA and levonorgestrel intrauterine system Many studies in literature reported the negative effect of combined oral contraceptive pills COCs on female sexual function due to decrease in bioavailability of testosterone and increase level of sex hormone binding globulin SHBG which leads to decrease in free testosterone level contributes to dysfunction
However the progesterone only methods contains no estrogen so it has less effect on sex hormone binding globulin and therefore less effect on free testosterone DMPA injectable progestins is an injectable progestin is a highly reliable form of contraception Nelson in 1996 found that about 6 of women using DMPA reported either lost or decreased libido More recent study by Fortenberry in 2011 reported that DMPA had no effect on sexual interest compared with nonusers of any hormonal method of contraception in an adolescent population The etonogestrel implant Implanon is a single rod that is inserted into the medial side of non dominant upper arm Although in general it is very effective and has relatively low side effect a decreased libido has been noted
Cerazette is a progestogen-only contraceptive pill containing 75 micrograms of desogestrel It acts mainly by inhibiting ovulation Cerazette users also may complain of decreased libido
The estrogen is the main hormone which responsible for vitality of the pelvic organ especially the vagina The main mechanism of action of the DMPA Implanon and Cerazette is inhibition of ovulation which leads to decrease in the estrogen level which causes a drop in blood flow in uterine artery and accordingly the vagina artery That can affect vaginal lubrication causing the vagina to be too dry for comfortable sex
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None