Ignite Creation Date:
2024-05-05 @ 10:23 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005383
Status:
COMPLETED
Last Update Posted:
2016-02-18
First Post:
2000-05-25
Brief Title:
Anger and Cardiovascular Risk in Urban Youth
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2002-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To examine anger and cardiovascular disease risk in urban youth The project studied patterns of hemodynamic responses to social and nonsocial stressors ambulatory blood pressure BP fasting insulin fasting glucose lipid profiles and central obesity in adolescents from a wide range of socioeconomic status SES backgrounds
Detailed Description:
BACKGROUND
Urban adolescents at high risk for cardiovascular disease CVD exhibit a pattern of hemodynamic responses that a is evoked by social encounters that arouse anger defensiveness and distrust b appears related to increased insulin resistance c is more pronounced in males and African Americans and d may constitute a pathway via which chronic exposure to stressful social environments increases CVD risk
DESIGN NARRATIVE
There were four studies Study 1 in the first two years measured hemodynamics in 200 subjects to test the hypothesis that hostile distrust was associated with increased total peripheral resistance TPR response to social challenge and that adolescents exhibiting this response pattern had elevated levels of ambulatory BP fasting insulin glucose blood lipids and central obesity Study 2 followed 200 subjects for four years to determine if defensive hostility and distrust were related to tracking at higher levels of BP measured every 6 months and insulin glucose cholesterol measured once per year Study 3 in years 3 and 4 evaluated the influence of race on the cross-situational consistency of hostile distrustBP by measuring the latter responses in 200 adolescents during structured encounters with a friend of the same race and sex an unfamiliar same-race peer and an unfamiliar other-race peer black or white Study 4 evaluated video and audiotape recordings from Studies 1 and 3 to test the hypothesis that distrustful individuals expressed more hostile affect in encounters with others elicited more negative treatment were perceived as hostile regardless of observer race or gender and thus experienced chronic health-damaging interpersonal stress Study 4 data were used to examine the possibility that hostile distrust is related to exposure to crime poverty and racial discrimination
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Urban adolescents at high risk for cardiovascular disease CVD exhibit a pattern of hemodynamic responses that a is evoked by social encounters that arouse anger defensiveness and distrust b appears related to increased insulin resistance c is more pronounced in males and African Americans and d may constitute a pathway via which chronic exposure to stressful social environments increases CVD risk
DESIGN NARRATIVE
There were four studies Study 1 in the first two years measured hemodynamics in 200 subjects to test the hypothesis that hostile distrust was associated with increased total peripheral resistance TPR response to social challenge and that adolescents exhibiting this response pattern had elevated levels of ambulatory BP fasting insulin glucose blood lipids and central obesity Study 2 followed 200 subjects for four years to determine if defensive hostility and distrust were related to tracking at higher levels of BP measured every 6 months and insulin glucose cholesterol measured once per year Study 3 in years 3 and 4 evaluated the influence of race on the cross-situational consistency of hostile distrustBP by measuring the latter responses in 200 adolescents during structured encounters with a friend of the same race and sex an unfamiliar same-race peer and an unfamiliar other-race peer black or white Study 4 evaluated video and audiotape recordings from Studies 1 and 3 to test the hypothesis that distrustful individuals expressed more hostile affect in encounters with others elicited more negative treatment were perceived as hostile regardless of observer race or gender and thus experienced chronic health-damaging interpersonal stress Study 4 data were used to examine the possibility that hostile distrust is related to exposure to crime poverty and racial discrimination
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL052080 | NIH | None | httpsreporternihgovquickSearchR01HL052080 |