Ignite Creation Date:
2024-05-05 @ 12:00 PM
Last Modification Date:
2024-10-26 @ 9:18 AM
Study NCT ID:
NCT00202358
Status:
UNKNOWN
Last Update Posted:
2008-06-17
First Post:
2005-09-12
Brief Title:
Perioperative Effect of Atenolol on Cytokine Profiles
Sponsor:
Saini Foundation
Organization:
Saini Foundation
Study Overview
Official Title:
The Effect of Perioperative Atenolol on Post-Operative Cytokines
Status:
UNKNOWN
Status Verified Date:
2008-06
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Studies have shown that beta-blockers such as atenolol when given in the perioperative period reduce morbidity and mortality One study showed that atenolol given just during the surgery period seemed to improve outcomes up to 2 years later This is hard to explain since beta-blockers act on the body by blocking the effects of adrenalin and thereby lowering heart rate and blood pressure
This study is designed to find out if perioperative atenolol might exert its long term effects through an anti-inflammatory mechanism rather than by lowering heart rate and blood pressure It is known that inflammation increases after surgery as part of the healing process However it is also becoming clear that low-grade chronic inflammation can also lead to long term adverse effects
This study is designed to find out if perioperative atenolol might exert its long term effects through an anti-inflammatory mechanism rather than by lowering heart rate and blood pressure It is known that inflammation increases after surgery as part of the healing process However it is also becoming clear that low-grade chronic inflammation can also lead to long term adverse effects
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None