Ignite Creation Date:
2025-12-24 @ 3:37 PM
Ignite Modification Date:
2026-01-04 @ 4:59 PM
Study NCT ID:
NCT06381492
Status:
RECRUITING
Last Update Posted:
2025-10-15
First Post:
2024-04-19
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Quantifying Patellar Tendon Microstructure Using DTI
Sponsor:
University of Wisconsin, Madison
Organization:
Study Overview
Official Title:
Quantifying Patellar Tendon Microstructure Using Diffusion Tensor Imaging
Status:
RECRUITING
Status Verified Date:
2024-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this observational study is to understand how diffusion tensor imaging (DTI) relates to other traditional measures and knee function. The main question it aims to answer is:
Will regions of known patellar tendon pathology present with smaller DTI scalar parameters, shorter fiber length, and lower fiber density compared to the contralateral tendon and healthy regions in the ipsilateral tendon.
Participants will:
* undergo MRI and ultrasound imaging
* perform knee function test
* complete questionnaires
Will regions of known patellar tendon pathology present with smaller DTI scalar parameters, shorter fiber length, and lower fiber density compared to the contralateral tendon and healthy regions in the ipsilateral tendon.
Participants will:
* undergo MRI and ultrasound imaging
* perform knee function test
* complete questionnaires
Detailed Description:
Patellar tendon injuries are commonly accompanied by macrostructural alterations captured on common imaging modalities, and the extent of these alterations correlate to knee joint function. Evidence for using tendon macrostructure for diagnosis and prognosis of tendon injuries is not as clear, suggesting that these imaging modalities are not providing a complete picture of the alterations. Diffusion tensor imaging (DTI) tractography can quantify tendon microstructures that underlie the alterations in pathological tendons and shows promising results in healthy tendons. This study is the first step in evaluating whether tendon microstructure captured using DTI technology can be applied as a biomarker to optimize treatment for patellar tendon injuries.
Study Oversight
Has Oversight DMC:
True
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
True
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
Secondary ID Infos
| Secondary ID | Type | Domain | Link | View |
|---|---|---|---|---|
| 1K99AR085752-01 | NIH | None | https://reporter.nih.gov/quic… | View |
| A536130 | OTHER | UW Madison | View | |
| SMPH/ORTHO&REHAB/PHYS THER | OTHER | UW Madison | View | |
| Protocol Version 04/30/2025 | OTHER | UW Madison | View |