Ignite Creation Date:
2024-05-05 @ 11:59 AM
Last Modification Date:
2024-10-26 @ 9:18 AM
Study NCT ID:
NCT00207909
Status:
COMPLETED
Last Update Posted:
2016-06-14
First Post:
2005-09-13
Brief Title:
Study of Patients With Acute Renal Failure on CVVH
Sponsor:
Childrens Healthcare of Atlanta
Organization:
Childrens Healthcare of Atlanta
Study Overview
Official Title:
The Role of Hemodynamics Cytokine Response and Modulators of Apoptosis on Urine Output in Patients With Acute Renal Failure on CVVH
Status:
COMPLETED
Status Verified Date:
2016-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Acute kidney failure is common in children in the Pediatric Intensive Care Unit PICU You are being asked to participate in this study because your child is being treated for kidney failure with continuous veno-venous hemofiltration CVVH CVVH is a continuous gentle form of removing excess fluids and small wastes from the blood similar to kidney dialysis artificial kidney It is an accepted therapy for temporary support of kidney failure In some patients with acute kidney failure beginning CVVH is followed by a temporary decrease of urine output The reason why this happens is currently unknown The purpose of this study is to determine why this happens
Detailed Description:
Acute renal failure is common in children in the pediatric intensive care unit Renal replacement therapies such as peritoneal dialysis PD intermittent hemodialysis IHD and continuous venovenous hemofiltration CVVH have been used in the management of acute renal failure CVVH is becoming increasingly utilized in pediatric acute renal failure However in patients who have acute renal failure the institution of CVVH is often followed by a progression to oliguria or anuria The underlying pathophysiology of this change is unknown We believe that this progression is influenced by changes in the renin-angiotensin axis cytokine response and other modifiers of renal hemodynamics By serially measuring components of those systems this study will attempt to elucidate the pathophysiology of the decreased urine output seen with institution of CVVH Once this process is understood future studies should focus on prevention and treatment of this complication
General Hypothesis
The decrease in urine output seen after the initiation of CVVH is associated with increased angiotensin converting enzyme ACE levels increased renin activity increased angiotensin II levels increased atrial naturetic peptide ANP levels increased endothelin-1 levels increased arginine vasopressin AVP levels and alterations of cytokine levels and modulators of apoptosis
General Hypothesis
The decrease in urine output seen after the initiation of CVVH is associated with increased angiotensin converting enzyme ACE levels increased renin activity increased angiotensin II levels increased atrial naturetic peptide ANP levels increased endothelin-1 levels increased arginine vasopressin AVP levels and alterations of cytokine levels and modulators of apoptosis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 06585 | None | None | None |