Ignite Creation Date:
2024-05-05 @ 11:59 AM
Last Modification Date:
2024-10-26 @ 9:18 AM
Study NCT ID:
NCT00202176
Status:
COMPLETED
Last Update Posted:
2011-04-19
First Post:
2005-09-09
Brief Title:
Effects of Bronchodilators in Mild Chronic Obstructive Pulmonary Disease COPD
Sponsor:
Queens University
Organization:
Queens University
Study Overview
Official Title:
The Effects of Bronchodilators on Exertional Dyspnea and Exercise Performance in Mild Chronic Obstructive Pulmonary Disease COPD Patients and Healthy Elderly Subjects
Status:
COMPLETED
Status Verified Date:
2011-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In people with mild COPD the ability to exhale air from the lungs is partly limited because of narrowing and collapse of the airways This results in the trapping of air within the lungs and over-distention of the lungs and chest lung hyperinflation
Breathing at high lung volumes hyperinflation is an important cause of breathing discomfort dyspnea in people with COPD Bronchodilators help to relax muscles in the airways or breathing tubes Bronchodilators are often prescribed if a cough occurs with airway narrowing as this medication can reduce coughing wheezing and shortness of breath Bronchodilators can be taken orally through injection or through inhalation and begin to act almost immediately but with the effect only lasting 4-6 hours The main purpose of this study is to examine the effects of inhaled bronchodilators on breathing discomfort and exercise endurance in patients with mild COPD
Breathing at high lung volumes hyperinflation is an important cause of breathing discomfort dyspnea in people with COPD Bronchodilators help to relax muscles in the airways or breathing tubes Bronchodilators are often prescribed if a cough occurs with airway narrowing as this medication can reduce coughing wheezing and shortness of breath Bronchodilators can be taken orally through injection or through inhalation and begin to act almost immediately but with the effect only lasting 4-6 hours The main purpose of this study is to examine the effects of inhaled bronchodilators on breathing discomfort and exercise endurance in patients with mild COPD
Detailed Description:
In people with mild COPD the ability to exhale air from the lungs is partly limited because of narrowing and collapse of the airways This results in the trapping of air within the lungs and over-distention of the lungs and chest - this is known as lung hyperinflation We believe that breathing at high lung volumes hyperinflation is an important cause of breathing discomfort dyspnea in people with COPD Bronchodilators help to relax muscles in the airways or breathing tubes Bronchodilators are often prescribed if a cough occurs with airway narrowing this medication can reduce coughing wheezing and shortness of breath Bronchodilators can be taken orally through injection or through inhalation and begin to act almost immediately but with the effect only lasting 4-6 hours The main purpose of this study is to examine the effects of inhaled bronchodilators on breathing discomfort and exercise endurance in patients with mild COPD
Each subject will attend 4 visits to the laboratory Visit 1 screening visit will involve a record of medical history medications used anthropometrics measurements questionnaires breathing tests an incremental cycle exercise test and a constant-workload cycle exercise test Visit 2 will involve breathing tests and a constant-workload cycle exercise test Visits 3 and 4 will involve breathing tests and a constant-workload cycle exercise test after subjects have been randomized to either placebo or Atrovent These visits will be done on separate days and subjects will receive the two above treatments in random order
Each subject will attend 4 visits to the laboratory Visit 1 screening visit will involve a record of medical history medications used anthropometrics measurements questionnaires breathing tests an incremental cycle exercise test and a constant-workload cycle exercise test Visit 2 will involve breathing tests and a constant-workload cycle exercise test Visits 3 and 4 will involve breathing tests and a constant-workload cycle exercise test after subjects have been randomized to either placebo or Atrovent These visits will be done on separate days and subjects will receive the two above treatments in random order
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None