Ignite Creation Date:
2024-05-06 @ 7:27 AM
Last Modification Date:
2024-10-26 @ 11:48 AM
Study NCT ID:
NCT02532439
Status:
TERMINATED
Last Update Posted:
2024-02-06
First Post:
2015-08-21
Brief Title:
Bone Microarchitectural Database Constitution From HR-pQCT Device in Clinical Situation Potentially Associated With Bone Loss
Sponsor:
Centre Hospitalier Universitaire de Saint Etienne
Organization:
Centre Hospitalier Universitaire de Saint Etienne
Study Overview
Official Title:
Bone Microarchitectural Database Constitution From High Resolution Peripheral Quantitative Computed Tomography HR-pQCT Device in Clinical Situation Potentially Associated With Bone Loss
Status:
TERMINATED
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
DMPOs
Brief Summary:
Bone fracture occurrence is associated with an increasing of morbidity and mortality Some factors of fracture occurrence have been highlighted For example some diseases or therapy are known to increased risk of bone fracture only in some patients Accordingly it is important for clinicians to identify patients at risk for bone fracture Right now various tools are available for the clinicians
clinical exam
bone mineral density assessed by Dual Energy X-ray Absorptiometry DEXA
an algorithm based on interrogation clinical exam and bone mineral density However prediction of bone fracture risk needs to be improved since only 50 of bone fractures can be predicted DEXA provides information for fracture risk estimation but it is unable to distinguish cortical part to trabecular part It also fails to quantify the microstructural properties that influence bone strength Bone microarchitecture including the cortical compartment can now be assessed in vivo by the HR-pQCT This technique allows access to several parameters on the one hand the volumetric bone mineral density for the whole area measured as well as cortical and trabecular regions and on the other hand the thickness and cortical porosity and the number of trabecular their orientation and distribution
Thus the HR-pQCT allows realizing a virtual bone biopsy and provides information on cortical and trabecular bone microarchitecture This is the only noninvasive way to assess cortical and trabecular bone microarchitecture
clinical exam
bone mineral density assessed by Dual Energy X-ray Absorptiometry DEXA
an algorithm based on interrogation clinical exam and bone mineral density However prediction of bone fracture risk needs to be improved since only 50 of bone fractures can be predicted DEXA provides information for fracture risk estimation but it is unable to distinguish cortical part to trabecular part It also fails to quantify the microstructural properties that influence bone strength Bone microarchitecture including the cortical compartment can now be assessed in vivo by the HR-pQCT This technique allows access to several parameters on the one hand the volumetric bone mineral density for the whole area measured as well as cortical and trabecular regions and on the other hand the thickness and cortical porosity and the number of trabecular their orientation and distribution
Thus the HR-pQCT allows realizing a virtual bone biopsy and provides information on cortical and trabecular bone microarchitecture This is the only noninvasive way to assess cortical and trabecular bone microarchitecture
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2014-A00771-46 | OTHER | ANSM | None |