Ignite Creation Date:
2024-05-05 @ 11:59 AM
Last Modification Date:
2024-10-26 @ 9:18 AM
Study NCT ID:
NCT00204945
Status:
COMPLETED
Last Update Posted:
2019-02-08
First Post:
2005-09-13
Brief Title:
Catheterization Laboratory Study Acute Responses in Diastolic Heart Failure
Sponsor:
University of Wisconsin Madison
Organization:
University of Wisconsin Madison
Study Overview
Official Title:
Acute Responses in Diastolic Heart Failure
Status:
COMPLETED
Status Verified Date:
2019-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
1 Research question What is the response of the hearts pumping function to changes in heart chamber pressures
2 Experimental design Patients undergoing routine cardiac catheterization will be studied A thermodilution pulmonary artery catheter will be inserted through a venous sheath and threaded into the pulmonary artery After several minutes of quiet rest baseline hemodynamics will be obtained including a determination of cardiac output using thermodilution techniques and 30 seconds of pressure recordings from the left ventricle and proximal aorta In addition a brief echocardiogram will be performed to determine ejection fraction and indices of diastolic filling Finally arterial tonometry will be obtained in quick succession from the brachial radial femoral and carotid arteries Following the collection of baseline data a bolus and infusion of nesiritide will be started After 10 minutes of nesiritide infusion with the drug still infusing a full set of invasive hemodynamics will again be obtained as well as brief echocardiographic and arterial tonometry examinations
2 Experimental design Patients undergoing routine cardiac catheterization will be studied A thermodilution pulmonary artery catheter will be inserted through a venous sheath and threaded into the pulmonary artery After several minutes of quiet rest baseline hemodynamics will be obtained including a determination of cardiac output using thermodilution techniques and 30 seconds of pressure recordings from the left ventricle and proximal aorta In addition a brief echocardiogram will be performed to determine ejection fraction and indices of diastolic filling Finally arterial tonometry will be obtained in quick succession from the brachial radial femoral and carotid arteries Following the collection of baseline data a bolus and infusion of nesiritide will be started After 10 minutes of nesiritide infusion with the drug still infusing a full set of invasive hemodynamics will again be obtained as well as brief echocardiographic and arterial tonometry examinations
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| K23 AGO01022 | None | None | None |