Ignite Creation Date:
2024-05-05 @ 11:59 AM
Last Modification Date:
2024-10-26 @ 9:18 AM
Study NCT ID:
NCT00200863
Status:
COMPLETED
Last Update Posted:
2014-08-12
First Post:
2005-09-12
Brief Title:
Effects of Different Colors of Light on Human Physiology
Sponsor:
Brigham and Womens Hospital
Organization:
Brigham and Womens Hospital
Study Overview
Official Title:
Mechanism Underlying the Effects of Blue Light in Humans
Status:
COMPLETED
Status Verified Date:
2014-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will determine which color of light is most effective in stimulating a range of biological functions in humans including activation of sleep-wake regulatory system alertness performance microsleeps brain activity activation of the nervous system heart rate temperature blood pressure breathing rate and shifting the timing of the internal 24-hour circadian pacemaker
Detailed Description:
Light has long been proposed to have a stimulatory effect on a range of biological functions in humans including increased feelings of activation such as improved alertness or ability to perform The mechanisms underlying how light stimulates these neurobiological systems remain to be elucidated We propose to investigate the effects of different colors of light on human physiology and in particular test the claims that specific colors of light preferentially stimulate neurobiological physiological and hormonal systems Using classical photobiological techniques we will construct action spectra for the effects of different colors of light on a range of non-image forming responses in humans
We will test the hypotheses that 1 light-induced activation of the neurobiological sleep-wake regulatory system as indicated by increased alertness faster reaction time suppression of EEG alpha activity microsleeps and slow rolling eye movements and suppression of pineal melatonin is most sensitive to retinal exposure to short wavelength blue light 460 nm compared to equal photons of other colors of visible light 2 light-induced activation of autonomic and hypothalamic-pituitary-adrenal axis measures of arousal as indicated by increased heart rate variability core body temperature blood pressure respiration rate plasma cortisol levels and urinary catecholamines is most sensitive to exposure to short wavelength blue light 460 nm compared to equal photons of other colors 3 phase shifts of the human circadian pacemaker as assessed by changes in temperature melatonin and cortisol rhythms are most sensitive to exposure to short wavelength blue light 460 nm compared to equal photons of other colors The resultant action spectra will help to identify the photoreceptor mechanisms by which light activates arousal and circadian resetting these non-image-forming physiological responses and enable us to distinguish between major candidate photoreceptive mechanisms including potential novel photoreceptor systems that might mediate such responses
We will test the hypotheses that 1 light-induced activation of the neurobiological sleep-wake regulatory system as indicated by increased alertness faster reaction time suppression of EEG alpha activity microsleeps and slow rolling eye movements and suppression of pineal melatonin is most sensitive to retinal exposure to short wavelength blue light 460 nm compared to equal photons of other colors of visible light 2 light-induced activation of autonomic and hypothalamic-pituitary-adrenal axis measures of arousal as indicated by increased heart rate variability core body temperature blood pressure respiration rate plasma cortisol levels and urinary catecholamines is most sensitive to exposure to short wavelength blue light 460 nm compared to equal photons of other colors 3 phase shifts of the human circadian pacemaker as assessed by changes in temperature melatonin and cortisol rhythms are most sensitive to exposure to short wavelength blue light 460 nm compared to equal photons of other colors The resultant action spectra will help to identify the photoreceptor mechanisms by which light activates arousal and circadian resetting these non-image-forming physiological responses and enable us to distinguish between major candidate photoreceptive mechanisms including potential novel photoreceptor systems that might mediate such responses
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01AT002129-01 | NIH | None | httpsreporternihgovquickSearchR01AT002129-01 |