Ignite Creation Date:
2024-05-06 @ 7:17 AM
Last Modification Date:
2024-10-26 @ 11:47 AM
Study NCT ID:
NCT02509559
Status:
COMPLETED
Last Update Posted:
2015-07-28
First Post:
2015-06-30
Brief Title:
Effects of Propranolol vs Placebo on Information Processing During Presentation of Emotionally Arousing Pictures
Sponsor:
University Medicine Greifswald
Organization:
University Medicine Greifswald
Study Overview
Official Title:
Effects of Propranolol vs Placebo on Information Processing During Presentation of Emotionally Arousing Pictures After Single Dose 80 mg Administration and Relationships Between ß1- and ß2-adrenoreceptors Genotype and Both the Information Processing and the Propranolol Effects in 64 Healthy Male Subjects
Status:
COMPLETED
Status Verified Date:
2015-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
BBEmoMem_G
Brief Summary:
The main objective of the present study is to combine two lines of research investigating the interaction between emotional processing and memory performance on both behavioral and electrophysiological levels and its modulation by ß-blockade
Concerning pharmacological manipulations with ß-blockers there are no studies which investigated the effects of propranolol on electrophysiological ERPs and behavioral measures of recognition memory along with their codependence on individual variations of adrenergic receptors polymorphisms Till now also the findings about genetic influences of ADRB1 and ADRB2 on recognition memory for emotional contents are lacking
Therefore the current investigation has been designed to replicate the former results which revealed reduced ERP correlates of recognition memory for emotional pictures due to administration of ß-blocker propranolol Furthermore investigators goal is to test whether there are any differences between carriers of genetic variants of the ADRB1 and ADRB2 in memory performance andor changes in event-related potentials and in propranolol influences on the above mentioned processes
In conclusion investigators hypothesize 1 a memory advantage of emotionally arousing stimuli over emotionally neutral pictures 2 more pronounced ERP components EPN LPP old-new effect associated with encoding and memory for emotional stimuli 3 a reduction of electrocortical correlates of emotional recognition memory old-new effect caused by propranolol 4 a potential impact of genetic variants of the ADRB1 and ADRB2 on the emotional information processing and memory formation alone and on the propranolol modulation of those processes
Furthermore investigators hypothesize additional pharmacodynamic effects of propranolol such as influence on skin- conductance pulse waves burdening heart frequency pulmonary function and metabolomics which might depend on the ADRB1 and ADRB2 genotype
Concerning pharmacological manipulations with ß-blockers there are no studies which investigated the effects of propranolol on electrophysiological ERPs and behavioral measures of recognition memory along with their codependence on individual variations of adrenergic receptors polymorphisms Till now also the findings about genetic influences of ADRB1 and ADRB2 on recognition memory for emotional contents are lacking
Therefore the current investigation has been designed to replicate the former results which revealed reduced ERP correlates of recognition memory for emotional pictures due to administration of ß-blocker propranolol Furthermore investigators goal is to test whether there are any differences between carriers of genetic variants of the ADRB1 and ADRB2 in memory performance andor changes in event-related potentials and in propranolol influences on the above mentioned processes
In conclusion investigators hypothesize 1 a memory advantage of emotionally arousing stimuli over emotionally neutral pictures 2 more pronounced ERP components EPN LPP old-new effect associated with encoding and memory for emotional stimuli 3 a reduction of electrocortical correlates of emotional recognition memory old-new effect caused by propranolol 4 a potential impact of genetic variants of the ADRB1 and ADRB2 on the emotional information processing and memory formation alone and on the propranolol modulation of those processes
Furthermore investigators hypothesize additional pharmacodynamic effects of propranolol such as influence on skin- conductance pulse waves burdening heart frequency pulmonary function and metabolomics which might depend on the ADRB1 and ADRB2 genotype
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None