Ignite Creation Date:
2024-05-05 @ 11:59 AM
Last Modification Date:
2024-10-26 @ 9:17 AM
Study NCT ID:
NCT00192790
Status:
COMPLETED
Last Update Posted:
2007-04-11
First Post:
2005-09-12
Brief Title:
Pain Perception is Attenuated in Patients With Painless Myocardial Infarction
Sponsor:
Rambam Health Care Campus
Organization:
Rambam Health Care Campus
Study Overview
Official Title:
Clinical and Experimental Pain Perception is Attenuated in Patients With Painless Myocardial Infarction
Status:
COMPLETED
Status Verified Date:
2007-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To explore whether reduced systemic pain perception in response to painful stimuli and personality pain related variables characterizes silent MI patients
Detailed Description:
Objective Silent myocardial infarction MI is an event of severe myocardial ischemia without pain experience The lack of pain alarm leads to increased morbidity and mortality because the patients do not sick timely medical treatment This study aims to explore whether reduced systemic pain perception in response to painful stimuli and personality pain related variables characterizes silent MI patients
Methods Level of chest pain intensity was assessed by visual analogue scale VAS range from 0 no pain to 100 maximal pain Heat pain threshold magnitude estimation of supra-threshold painful stimuli at 47ºC as well as pain catastrophizing scores were assessed in 90 acute MI patients mean age 66121 range 33-79 with chest pain n65 and without pain symptomsn25 All stimuli were performed by Thermal Sensory Analysis TSA and applied to the right forearm
Results The demographic variables history of ischemic heart risk factors for coronary artery disease ST-T segment changes on ECG and troponin levels were similar in both groups Greater intensity of chest pain VAS scores was inversely correlated with lower pain threshold r -0417 p0001 and directly associated with higher pain scores in response to the heat pain r0354 p0002 Patients with painful MI demonstrated lower pain threshold 41936 vs 44938 p0001 higher VAS scores in response to the supra-threshold painful stimuli 502 218 vs 270252 p0002 and higher catastrophizing level 106120 vs 5488 p0032 Chest pain complaint was not related to ST-T changes as well as concomitant diseases
Conclusions This study suggests that reduced systemic pain perception as well as cognitive personality variables play an important role in the etiology of Silent MI
Methods Level of chest pain intensity was assessed by visual analogue scale VAS range from 0 no pain to 100 maximal pain Heat pain threshold magnitude estimation of supra-threshold painful stimuli at 47ºC as well as pain catastrophizing scores were assessed in 90 acute MI patients mean age 66121 range 33-79 with chest pain n65 and without pain symptomsn25 All stimuli were performed by Thermal Sensory Analysis TSA and applied to the right forearm
Results The demographic variables history of ischemic heart risk factors for coronary artery disease ST-T segment changes on ECG and troponin levels were similar in both groups Greater intensity of chest pain VAS scores was inversely correlated with lower pain threshold r -0417 p0001 and directly associated with higher pain scores in response to the heat pain r0354 p0002 Patients with painful MI demonstrated lower pain threshold 41936 vs 44938 p0001 higher VAS scores in response to the supra-threshold painful stimuli 502 218 vs 270252 p0002 and higher catastrophizing level 106120 vs 5488 p0032 Chest pain complaint was not related to ST-T changes as well as concomitant diseases
Conclusions This study suggests that reduced systemic pain perception as well as cognitive personality variables play an important role in the etiology of Silent MI
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None