Ignite Creation Date:
2024-05-06 @ 7:12 AM
Last Modification Date:
2024-10-26 @ 11:46 AM
Study NCT ID:
NCT02490397
Status:
TERMINATED
Last Update Posted:
2021-06-07
First Post:
2015-06-24
Brief Title:
Impact of Daylight on Patients With Acute Myocardial Infarction
Sponsor:
University of Colorado Denver
Organization:
University of Colorado Denver
Study Overview
Official Title:
Impact of Daylight on Period 2 Protein and Glycolytic Enzymes in Human Buccal Mucosa and Blood Samples
Status:
TERMINATED
Status Verified Date:
2021-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
not enough participants
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The study tests if intense light could be a potential therapy in humans after myocardial infarction by inducing Per2
Detailed Description:
Damage to the heart caused by a myocardial infarction heart attack occurs most often during the early morning hours 6AM Thus the involvement of the circadian system circa approximately day has been suggested The circadian system in humans or animals is based on the rotation of the earth with day and night phases When humans or animals wake up light shines in their eyes and the body receives a signal that the day starts For the human body it means that certain proteins named clock period etc are produced The protein that determines the length of a day awake and sleep period is called Period 2 Per2 Recent data indicated that the Per2 protein in hearts from mice is induced after daylight exposure daylight with an intensity comparable to a bright day at the beach was used approx 10 000 LUX This more Per2 was able to protect the heart from being damaged by no blood going to the heart protection from a heart attack This protection was based on a more efficient use of sugars carbohydrates Thereby the heart needs less oxygen Current data indicate that human Per2 is also induced by light exposure and can be detected in human plasma samples
In this study Per2 transcript and protein levels will be analyzed in patients that just experienced a heart attack with and without intense light daylight therapy utilizing blood samples erythrocytes and leukocytes
In this study Per2 transcript and protein levels will be analyzed in patients that just experienced a heart attack with and without intense light daylight therapy utilizing blood samples erythrocytes and leukocytes
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None